Xenotropic murine leukemia virus (MLV)-related virus (XMRV) was first described in 2006 in some human prostate cancers. But it drew little attention until 2009, when it was also found, as infectious virus and as MLV-related DNA, in samples from people suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This discovery was rapidly followed by efforts of the international research community to understand the significance of the association and its potential to spread widely as an important human pathogen. Within a few years, efforts by researchers worldwide failed to repeat these findings, and mounting evidence for laboratory contamination with mouse-derived virus and viral DNA sequences became accepted as the explanation for the initial findings. As researchers engaged in these studies, we present here a historical review of the rise and fall of XMRV as a human pathogen, and we discuss the lessons learned from these events.

John M. Coffin

Mary F. Kearney

Annual Review of Virology

病毒学年度回顾交流了我们对动物、植物、细菌、古细菌、真菌和原生动物病毒的理解方面的令人兴奋的进展。评论突出了基础病毒学、病毒疾病机制、病毒与宿主相互作用以及对病毒感染的细胞和免疫反应的新思想和新方向，并巩固了病毒作为细胞功能独特有力探针的地位。病毒学年度评论于2016 年发布影响因子为 3.345 的期刊引文报告 (JCR)。

The Annual Review of Virology is an annual journal that communicates exciting advancements in our understanding of viruses affecting animals, plants, bacteria, archaea, fungi, and protozoa. The reviews highlight foundational virology, mechanisms of viral diseases, interactions between viruses and hosts, and new ideas and directions regarding cellular and immune responses to viral infections, reinforcing the status of viruses as unique and powerful probes of cellular function. This journal was first published in 2016 and has an impact factor of 3.345 according to the Journal Citation Reports (JCR).

《Annual Review of Virology》是一本年度期刊，交流了我们对动物、植物、细菌、古细菌、真菌和原生动物病毒理解方面的最新进展。期刊评论了基础病毒学、病毒疾病机制、病毒与宿主相互作用，以及对病毒感染的细胞和免疫反应的新思想和新方向，巩固了病毒作为细胞功能独特而有力的探针的地位。该期刊于2016年发布，影响因子为3.345（期刊引文报告，JCR）。

Category	Quartile
医学	1
医学, 病毒学	1

False Alarm: XMRV, Cancer, and Chronic Fatigue Syndrome

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