Radiomics is an emerging field of medical imaging that aims at improving the accuracy of diagnosis, prognosis, treatment planning and monitoring non-invasively through the automated or semi-automated quantitative analysis of high-dimensional image features. Specifically in the field of nuclear medicine, radiomics utilizes imaging methods such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) to evaluate biomarkers related to metabolism, blood flow, cellular activity and some biological pathways. Lung cancer ranks among the leading causes of cancer-related deaths globally, and radiomics analysis has shown great potential in guiding individualized therapy, assessing treatment response, and predicting clinical outcomes. In this review, we summarize the current state-of-the-art radiomics progress in lung cancer, highlighting the potential benefits and existing limitations of this approach. The radiomics workflow was introduced first including image acquisition, segmentation, feature extraction, and model building. Then the published literatures were described about radiomics-based prediction models for lung cancer diagnosis, differentiation, prognosis and efficacy evaluation. Finally, we discuss current challenges and provide insights into future directions and potential opportunities for integrating radiomics into routine clinical practice.

Yongbai Zhang

Wenpeng Huang

Hao Jiao

Lei Kang

EJNMMI Physics

EJNMMI PHYSICS 是一个国际平台，面向对物理问题特别感兴趣的核医学科学家、用户和采用者。作为欧洲核医学和分子成像杂志的配套期刊，该杂志采用多学科方法，欢迎原创材料和研究，重点是应用物理学和数学以及核医学中的成像系统工程和原型设计。这包括物理驱动的方法或物理支持的算法，促进早期临床采用核医学成像和治疗。

EJNMMI Physics is an international platform aimed at nuclear medicine scientists, users, and practitioners with a particular interest in physical issues. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, it adopts a multidisciplinary approach, welcoming original materials and research that focus on applied physics and mathematics, as well as imaging system engineering and prototype design in nuclear medicine. This includes physics-driven methods or physics-supported algorithms that facilitate the early clinical adoption of nuclear medicine imaging and therapy.

EJNMMI Physics 是一个国际平台，专注于核医学科学家、用户和采用者对物理问题的兴趣。作为欧洲核医学和分子成像杂志的配套期刊，本杂志采用多学科的方法，欢迎原创研究和材料，重点关注应用物理学、数学以及核医学中的成像系统工程和原型设计。这包括物理驱动的方法或物理支持的算法，以促进核医学成像和治疗在早期临床中的应用。

Category	Quartile
医学	2
医学, 核医学	2

PET radiomics in lung cancer: advances and translational challenges

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Journal Info

Category	Quartile
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING	2