Abstract Multicentric reticulohistiocytosis (MRH) is a rare disease characterized by erosive polyarthritis and nodular skin lesions which is associated with malignancy in some cases. We describe a 44‐year‐old woman with polyarthralgia, numerous skin nodules, mucosal lesions and elevated erythrocyte sedimentation rate who was admitted to hospital for further evaluation. Tissue biopsy of skin nodules showed large histiocytes with ground‐glass eosinophilic cytoplasm, typical of MRH. Clinical manifestation and radiological pattern of MRH may be misdiagnosed as other diseases like rheumatoid arthritis, psoriatic arthritis and nodal osteoarthritis, but histopathology the characteristic pattern can differentiate MRH from any other condition.

Mohammad Bagher OWLIA

Multicentric reticulohistiocytosis

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