Background A systemic inflammatory response is triggered in patients undergoing cardiothoracic surgery with cardiopulmonary bypass. This response is particularly evident in pediatric patients, especially if of low weight and after undergoing long cardio-pulmonary by-pass (CPB), and can severely impair surgical result. Objectives Adsorptive blood purification techniques have been proposed to limit this systemic inflammatory response. To test its efficacy, we added the hemoadsorption filter Jafron HA 380 to CPB in a very compromised pediatric patient who underwent heart transplantation. Method A 10-year-old single ventricle patient previously treated with Fontan operation was listed for heart transplantation due to the evidence of failing Fontan condition. He experienced many episodes of cardiac arrest and underwent heart transplantation in very compromised general and hemodynamic conditions. The hemoadsorption filter Jafron HA 380 was used for all the duration of CPB and the inflammatory biomarker Interleukin 6 (IL-6) was assayed. Results Post-operative outcome was uneventful and comparable to that of an elective pediatric heart transplantation. The Interleukin 6 (IL-6) levels showed an impressive post-operative reduction and after 2 days the IL-6 level was comparable with a typical uneventful post-transplant course. Conclusions The use of hemoadsorption filter can contribute to improve pediatric transplant results especially in very high-risk patients.

Carlo Pace Napoleone

Enrico Aidala

Maria Teresa Cascarano

Luca Deorsola

Stefania Iannandrea

Annalisa Longobardo

Enrico Bonaveglio

Mattia Zanin

Licia Peruzzi

Cardiorenal Medicine

《心肾医学》杂志探讨了肥胖和其他代谢异常促进心脏和肾脏疾病（心肾代谢综合征）发病和进展的机制。它为推进研究和临床实践提供了一个跨学科平台，专注于转化问题。

The journal "CardioRenal Medicine" explores the mechanisms by which obesity and other metabolic disorders contribute to the onset and progression of cardiovascular and renal diseases (cardiorenal metabolic syndrome). It provides an interdisciplinary platform for advancing research and clinical practice, focusing on translational issues.

《CardioRenal Medicine》杂志探讨肥胖及其他代谢异常如何促进心脏和肾脏疾病（心肾代谢综合征）的发生与发展。该期刊为研究和临床实践提供了一个跨学科的平台，专注于转化医学问题。

Category	Quartile
医学	4
医学, 心脏和心血管系统	4
医学, 泌尿学与肾脏学	4

Hemoadsorption contribution in failing Fontan pediatric heart transplantation

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Journal Info

Category	Quartile
UROLOGY & NEPHROLOGY	2