The metabolic syndrome refers to the co-occurrence of several known cardiovascular risk factors, including insulin resistance, obesity, atherogenic dyslipidemia and hypertension. These conditions are interrelated and share underlying mediators, mechanisms and pathways. There has been recent controversy about its definition and its utility. In this article, I review the current definitions for the metabolic syndrome and why the concept is important. It identifies a subgroup of patients with shared pathophysiology who are at high risk of developing cardiovascular disease and type 2 diabetes. By considering the central features of the metabolic syndrome and how they are related, we may better understand the underlying pathophysiology and disease pathogenesis. A comprehensive definition for the metabolic syndrome and its key features would facilitate research into its causes and hopefully lead to new insights into pharmacologic and lifestyle treatment approaches.

Paul L. Huang

Disease Models & Mechanisms

疾病模型与机制 (DMM) 是一本在线开放获取期刊，专注于使用模型系统更好地理解、诊断和治疗人类疾病。

DMM Disease Models and Mechanisms is an online open-access journal that focuses on using model systems to better understand, diagnose, and treat human diseases.

《DMM Disease Models and Mechanisms》是一本在线开放获取期刊，专注于通过模型系统深入理解、诊断和治疗人类疾病。

DMM Disease Models and Mechanisms

A comprehensive definition for metabolic syndrome

A comprehensive definition for the metabolic syndrome and its key features would facilitate research into its causes and hopefully lead to new insights into pharmacologic and lifestyle treatment approaches.

Category	Quartile
医学	3
医学, 病理学	2
医学, 细胞生物学	3

A comprehensive definition for metabolic syndrome

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