Abstract While bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this review, we highlight diverse examples of bioorthogonal reactions used to investigate the roles of biomolecules and biological processes as well as advanced imaging techniques within cellular organelles. These innovations hold great promise for therapeutic interventions in personalized medicine and precision therapies. We also address existing challenges related to the selectivity and trafficking of subcellular dynamics. Organelle-targeted bioorthogonal reactions have the potential to significantly advance our understanding of cellular organization and function, provide new pathways for basic research and clinical applications, and shape the direction of cell biology and medical research.

Veronika Šlachtová

Marek Chovanec

Michal Rahm

Milan Vrabel

Topics in Current Chemistry

当前化学主题对现代化学研究的当前和未来趋势进行了批判性评论。涵盖范围是化学科学的所有领域，包括与生物学、医学、物理学和材料科学等相关学科的接口。每个专题合集的目标是为学术界或工业界的非专业读者提供全面的深入了解正在出现的新研究领域，这对更大的科学受众感兴趣。

Topics in Current Chemistry provides critical reviews of current and future trends in modern chemical research. It covers all areas of chemical science, including interfaces with related disciplines such as biology, medicine, physics, and materials science. Each thematic collection aims to offer a comprehensive understanding of emerging research fields for non-specialist readers in academia or industry, appealing to a broader scientific audience.

《Topics in Current Chemistry》对现代化学研究的当前和未来趋势进行了深入的批判性评论。该期刊涵盖化学科学的所有领域，包括与生物学、医学、物理学和材料科学等相关学科的交叉领域。每个专题合集旨在为学术界和工业界的非专业读者提供对新兴研究领域的全面理解，以满足更广泛科学受众的兴趣。

Category	Quartile
化学	2
化学, 化学综合	2

Bioorthogonal Chemistry in Cellular Organelles

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	1