This paper develops a non-equilibrium thermodynamics approach to oncogenesis, with a particular focus on ‘symmetry breaking’. The Onsager phenomenological coefficients are introduced to show the biophysical and thermophysical properties of cellular systems with differences between normal and cancerous cells. Seebeck- and Peltier-like effects are introduced to simplify the description of heat exchange and ion fluxes, in an effort to characterize the distinct role of the cellular electric membrane potential. Our result indicate that oncogenesis leads to changes in: (i) the thermophysical properties of the cell cytoplasm, caused by differences in density and heat capacity, (ii) the interactions with the micro-environment, (iii) geometrical characteristics, both in fractal dimensions and in shape symmetry, and (iv) the constitutive properties of membrane fluxes. This presents a unifying biophysics concept for such diverse characteristics, and it may yield new diagnostic and therapeutic opportunities.

Umberto Lucia

Giulia Grisolia

Thomas S. Deisboeck

Atti della Accademia Peloritana dei Pericolanti. Classe di Scienze Fisiche, Matematiche e Naturali/Atti della Accademia Peloritana dei Pericolanti, Classe di Scienze Fisiche, Matematiche e Naturali

This journal is of a multi- and inter-disciplinary nature and covers a broad range of fields including mathematics, computer science, physics, chemistry, biology, earth sciences, and their intersection. History of science is also included within the topics addressed by the journal. The transactions of the Pelorian Academy started out as periodic news sheets containing the notes presented by the members of the Divisions into which the Academy has been and still is organized, according to subject areas. The publication of these notes for the Division (“Classe”) of Mathematical, Physical and Natural Sciences is the responsibility of the Editorial Committee, which is composed of the Director of the division with the role of Chairman, the Vice-Director, the Secretary and two or more other members. Besides original research articles, the journal also accepts texts from conferences and invited talks held in the Academy. These contributions are published in a different section of the journal. In addition to the regular issues, single monographic supplements are occasionally published which assemble reports and communications presented at congresses, symposia, seminars, study meetings and other scientific events organized by the Academy or under its patronage. Since 2004 these transactions have been published online in the form of an open access electronic journal.

The journal "AAPP Atti della Accademia Peloritana dei Pericolanti, Classe di Scienze Fisiche, Matematiche e Naturali" is multi- and inter-disciplinary in nature, covering a wide range of fields including mathematics, computer science, physics, chemistry, biology, earth sciences, and their intersections. It also addresses topics related to the history of science. The transactions of the Pelorian Academy began as periodic news sheets containing notes presented by members of the various divisions organized by subject area. The publication of these notes for the Division of Mathematical, Physical and Natural Sciences is managed by an Editorial Committee, which consists of the Director of the division (Chairman), the Vice-Director, the Secretary, and two or more additional members. In addition to original research articles, the journal accepts texts from conferences and invited talks held at the Academy, which are published in a separate section. Occasionally, single monographic supplements are published, compiling reports and communications presented at congresses, symposia, seminars, study meetings, and other scientific events organized by the Academy or under its patronage. Since 2004, these transactions have been published online as an open access electronic journal.

《AAPP Atti della Accademia Peloritana dei Pericolanti, Classe di Scienze Fisiche, Matematiche e Naturali》是一本多学科和跨学科的期刊，涵盖数学、计算机科学、物理、化学、生物、地球科学及其交叉领域。期刊还包括科学史相关主题。佩洛里塔学院的交易最初是以定期新闻简报的形式发布，包含学院各个学科分部成员提交的笔记。数学、物理和自然科学分部的出版工作由编辑委员会负责，该委员会由分部主任（主席）、副主任、秘书及两名或更多其他成员组成。除了原创研究文章，期刊还接受来自学院举办的会议和邀请讲座的文本，这些贡献会在期刊的不同部分发表。除了定期刊物外，偶尔还会出版单独的专题补充，汇集在学院或其赞助下组织的大会、研讨会、研讨会、学习会议及其他科学活动中提交的报告和通讯。自2004年以来，这些交易以开放获取电子期刊的形式在线发布。

A non-equilibrium thermodynamic approach to symmetry breaking in cancer

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Journal Info

Category	Quartile
MULTIDISCIPLINARY SCIENCES	3