The classification “gastrointestinal stromal tumor” (GIST) became commonplace in the 1990s and since that time various advances have characterized the GIST lineage of origin, tyrosine kinase mutations, and mechanisms of response and resistance to targeted therapies. In addition to tyrosine kinase mutations and their constitutive activation of downstream signaling pathways, GISTs acquire a sequence of chromosomal aberrations. These include deletions of chromosomes 14q, 22q, 1p, and 15q, which harbor putative tumor suppressor genes required for stepwise progression from microscopic, preclinical forms of GIST (microGIST) to clinically relevant tumors with malignant potential. Recent advances extend our understanding of GIST biology beyond that of the oncogenic KIT/PDGFRA tyrosine kinases and beyond mechanisms of KIT/PDGFRA-inhibitor treatment response and resistance. These advances have characterized ETV1 as an essential interstitial cell of Cajal-GIST transcription factor in oncogenic KIT signaling pathways, and have characterized the biologically distinct subgroup of succinate dehydrogenase deficient GIST, which are particularly common in young adults. Also, recent discoveries of MAX and dystrophin genomic inactivation have expanded our understanding of GIST development and progression, showing that MAX inactivation is an early event fostering cell cycle activity, whereas dystrophin inactivation promotes invasion and metastasis.

Inga-Marie Schaefer

Adrián Mariño-Enríquez

Jonathan A. Fletcher

Advances in Anatomic Pathology

ADVANCES IN ANATOMIC PATHOLOGY 提供了对解剖学和外科病理学关键发展的有针对性的报道。它涵盖了从基本形态到最先进的分子生物学技术的主题。该杂志从最近的世界文献中选择并有效地传达最重要的信息，并为管理日益增长的病理学信息流提供宝贵的帮助。

Advances in Anatomic Pathology offers targeted reporting on key developments in anatomic and surgical pathology. It covers a wide range of topics, from fundamental morphology to cutting-edge molecular biology techniques. The journal selects and effectively communicates the most important information from recent global literature, providing valuable assistance in managing the ever-growing flow of pathology information.

《Advances in Anatomic Pathology》提供了对解剖学和外科病理学关键发展的深入报道。该杂志涵盖从基本形态学到最先进的分子生物学技术的各个主题。它从最新的全球文献中筛选出最重要的信息，并有效地传达给读者，为管理日益增长的病理学信息流提供了宝贵的支持。

Category	Quartile
医学	2
医学, 病理学	2

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