▪ Abstract Insulin-like peptides (ILPs) exist in insects and are encoded by multigene families that are expressed in the brain and other tissues. Upon secretion, these peptides likely serve as hormones, neurotransmitters, and growth factors, but to date, few direct functions have been demonstrated. In Drosophila melanogaster, molecular genetic studies have revealed elements of a conserved insulin signaling pathway, and as in other animal models, it appears to play a key role in metabolism, growth, reproduction, and aging. This review offers (a) an integrated summary of the efforts to characterize the distribution of ILPs in insects and to define this pathway and its functions in Drosophila and (b) a few considerations for future studies of ILP endocrinology in insects.

Qi Wu

Mark R. Brown

Annual Review of Entomology

自 1956 年出版的《昆虫学年度评论》回顾了昆虫学领域的重大发展，包括生物化学和生理学、形态学和发育、行为和神经科学、生态学、农业昆虫学和害虫管理、生物防治、森林昆虫学、螨类和其他节肢动物、医学和兽医昆虫学、病理学、植物病害载体、遗传学、基因组学和系统学、进化和生物地理学。

Since its inception in 1956, the Annual Review of Entomology has provided comprehensive reviews of significant developments in the field of entomology. These reviews cover a wide range of topics, including biochemistry and physiology, morphology and development, behavior and neuroscience, ecology, agricultural entomology and pest management, biological control, forest entomology, mites and other arthropods, medical and veterinary entomology, pathology, plant disease vectors, genetics, genomics and systematics, evolution and biogeography.

《Annual Review of Entomology》自1956年出版以来，回顾了昆虫学领域的重大进展。这些进展涵盖了多个方面，包括生物化学与生理学、形态学与发育、行为与神经科学、生态学、农业昆虫学与害虫管理、生物防治、森林昆虫学、螨类及其他节肢动物、医学与兽医昆虫学、病理学、植物病害载体、遗传学、基因组学与系统学、进化与生物地理学。

Annu. Rev. Entomol.

SIGNALING AND FUNCTION OF INSULIN-LIKE PEPTIDES IN INSECTS

An integrated summary of the efforts to characterize the distribution of ILPs in insects and to define this pathway and its functions in Drosophila is offered and a few considerations for future studies of ILP endocrinology in insects are offered.

Category	Quartile
农林科学	1
农林科学, 昆虫学	1

SIGNALING AND FUNCTION OF INSULIN-LIKE PEPTIDES IN INSECTS

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