The mitochondrial unfolded protein response is an important component of the mitochondrial protein quality control program. It can effectively remove unfolded or misfolded proteins under stress, and maintain a stable and healthy mitochondrial pool. The mitochondrial unfolded protein response is coordinated by multiple signaling pathways. The classical ATF4/ATF5-CHOP pathway is induced by accumulation of unfolded or misfolded proteins in the mitochondrial matrix, which reduces stress toxicity by regulating molecular chaperones and proteases. Sirt3-FOXO3a-SOD2 pathway, located in the mitochondrial matrix, plays an important role in anti-oxidative damage. The ERα-NRF1-HTRA2 pathway mainly removes unfolded proteins in the mitochondrial membrane space and improves the quality control of mitochondrial proteins. These three signaling pathways work both independently and cooperatively to enhance mitochondrial capacity and maintain health under stress.

Chun-Wei Ma

Bing-Hong Gao

Shengli xuebao

Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.

Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and the Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS). It is published bimonthly by Science Press, China. APS primarily publishes original research articles in the field of physiology, as well as contributions from other biomedical disciplines and proceedings from conferences and symposia related to physiological sciences. In addition to 'Original Research Articles', the journal features columns such as 'Brief Review', 'Rapid Communication', 'Experimental Technique', and 'Letter to the Editor'. Articles are published in either Chinese or English, depending on the authors' submission.

《Acta Physiologica Sinica》由中国生理科学学会和中国科学院上海生命科学研究院主办，由科学出版社出版，发行频率为双月刊。该期刊主要发表生理学领域的原创研究文章，同时也欢迎其他生物医学学科的研究贡献，以及生理科学会议和研讨会的论文集。除了“原创研究文章”，期刊还设有“简评”、“快速通讯”、“实验技术”和“致编辑的信”等栏目。文章可以根据作者的提交选择中文或英文发表。

Unfolded protein response signaling in mitochondria

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