Synthetic analogues of CCK-4 in which Trp was replaced by D-Pro (peptide I), Thz (peptide II) and delta Pro (peptide III) have been studied for their insulin and glucagon releasing activities from the islets of Langerhans in vitro. Peptide I has been found to be the most potent insulin releaser among the three analogues and its activity is comparable to that of CCK-4. Unlike CCK-4, its three analogues (peptides I-III) do not stimulate the release of glucagon with basal concentration of glucose in the medium. However, with increasing glucose concentration, all the three analogues potentiate the glucose stimulus for insulin release.

Faiyaz Ahmad

Bijoy Kundu

Mohammed M. Khan

Anil K. Rastogi

Krishna B. Mathur

Jalil R. Kidwai

Acta Diabetologica Latina

Acta Diabetol Lat

Selective stimulation of insulin secretion by CCK-4 analogues having N-terminal modifications

N-端修饰的CCK-4类似物对胰岛素分泌的选择性刺激

Selective stimulation of insulin secretion by CCK-4 analogues having N-terminal modifications

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