APOE is one of the prominent genes involved in the increased risk of developing Alzheimer's disease, but its effect on cognition in patients who are not yet diagnosed with dementia or mild cognitive impairment is relatively understudied. We aimed to examine the effect of ApoE4 on cognitive performance in unimpaired middle-aged and elderly persons.Our study included 51 cognitively unimpaired participants divided into ApoE4 positive patients and controls by APOE genotyping. The following clinical and demographic characteristics were collected: age, gender, education, social status, BMI, history of medical or psychiatric disorders. Patients with current anxiety or depressive disorders were excluded. Cognitive function was evaluated using MMSE, Rey Auditory-Verbal Learning Test, Rey Complex Figure test, TMT A and B and verbal fluency test. The two groups were matched for age, sex, and education. Categorial data was analyzed using Chi-Square and continuous data using Student-T test (parametric variables) or Mann-Whitney test (non-parametric variables). Statistical significance was considered at p≤.05.There were 11 (21.6%) ApoE4 positive patients and 40 (78.4%) controls. There were no significant differences between the groups regarding socio-demographic and clinical characteristics. The ApoE4 positive group performed slightly worse on cognitive evaluations compared to controls but only the mean scores of the Rey Complex Figure Test - Memory reached statistical significance (p=.019).Cognitive evaluation generally rendered lower scores in the ApoE4 group compared to the control group. However, only visual memory impairment scores were significantly lower in the ApoE4 positive individuals than in controls.

N.A. Pavel

M.R. Paun

P.V. Matei

I. Dutu

C. Tudose

Balkan Journal of Medical Genetics

BALKAN JOURNAL OF MEDICAL GENETICS 是一份英文期刊，用于发表涉及医学遗传学所有分支的文章：人类细胞遗传学、分子遗传学、临床遗传学、免疫遗传学、肿瘤遗传学、药物遗传学、群体遗传学、遗传筛查和单基因和多基因疾病的诊断、产前和植入前基因诊断、遗传咨询、治疗和预防方面的进展。

The Balkan Journal of Medical Genetics is an English-language journal dedicated to publishing articles covering all branches of medical genetics, including human cytogenetics, molecular genetics, clinical genetics, immunogenetics, oncogenetics, pharmacogenetics, population genetics, genetic screening, and advancements in the diagnosis of single-gene and multi-gene diseases, prenatal and preimplantation genetic diagnosis, genetic counseling, treatment, and prevention.

《Balkan Journal of Medical Genetics》是一份英文期刊，专注于医学遗传学的各个领域，包括人类细胞遗传学、分子遗传学、临床遗传学、免疫遗传学、肿瘤遗传学、药物遗传学、群体遗传学、遗传筛查，以及单基因和多基因疾病的诊断、产前和植入前基因诊断、遗传咨询、治疗和预防等方面的最新进展。

Category	Quartile
医学	4
医学, 遗传学	4

APOE4 Status and cognitive function in middle-aged and elderly people

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