The last two decades have witnessed substantial advances in identifying synaptic plasticity responsible for behavioral changes in animal models of substance use disorder. We have learned the most about cocaine-induced plasticity in the nucleus accumbens and its relationship to cocaine seeking, so that is the focus in this review. Synaptic plasticity pointing to potential therapeutic targets has been identified mainly using two drug self-administration models: extinction-reinstatement and abstinence models. A relationship between cocaine seeking and potentiated AMPAR transmission in nucleus accumbens is indicated by both models. In particular, an atypical subpopulation—Ca2+-permeable or CP-AMPARs—mediates cue-induced seeking that persists even after long periods of abstinence, modeling the persistent vulnerability to relapse that represents a major challenge in treating substance use disorder. We review strategies to reverse CP-AMPAR plasticity; strategies targeting other components of excitatory synapses, including dysregulated glutamate uptake and release; and behavioral interventions that can be augmented by harnessing synaptic plasticity.

Marina E. Wolf

The Annual Review of Pharmacology and Toxicology

自 1961 年出版的《药理学和毒理学年度评论》涵盖了药理学和毒理学领域的重大发展，包括受体、转运蛋白、酶和化学试剂；药物开发科学；免疫系统、中枢和自主神经系统、胃肠系统、心血管系统、内分泌系统和肺系统等系统；和专题。

The Annual Review of Pharmacology and Toxicology, published since 1961, covers significant developments in the fields of pharmacology and toxicology, including research on receptors, transport proteins, enzymes, and chemical agents; the science of drug development; and topics related to various systems such as the immune system, central and autonomic nervous systems, gastrointestinal system, cardiovascular system, endocrine system, and pulmonary system.

《Annual Review of Pharmacology and Toxicology》自1961年出版，涵盖了药理学和毒理学领域的重要进展，包括受体、转运蛋白、酶和化学试剂的研究；药物开发的科学；以及免疫系统、中枢神经系统、自主神经系统、胃肠系统、心血管系统、内分泌系统和肺系统等多个系统的相关内容。

Category	Quartile
医学	1
医学, 药学	1
医学, 毒理学	1

Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics

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