Nodular marginal zone lymphoma (NMZL) is a small B-cell lymphoma involving only lymph nodes and is the least common form of MZL constituting about 10% of cases. Patients usually present with advanced disease which must be distinguished from extranodal MZL with lymph node spread. NMZL shares cytological and immunophenotypic features with MALT and splenic MZL , but has a less favorable prognosis than these two categories. It occurs mostly in adults and pediatric cases are rare. Different therapeutic approaches have been used in NMZL, but because of the small patient numbers involved, more definitive treatment is still anticipated. Recent studies suggest that it probably represents a separate entity within the broader indolent lymphoma category. In NMZL there is an emerging need to utilize novel agents, already available for indolent lymphomas. Prospective studies are required to evaluate their therapeutic efficacy for NMZL in the future.

Tamar Tadmor

Aaron Polliack

Best Practice & Research Clinical Haematology

BEST PRACTICE & RESEARCH CLINICAL HEMATOLOGY 发表评论文章，将最新原创研究文章的结果整合到实用的、基于证据的评论文章中。这些文章旨在解决诊断、治疗和患者管理的关键临床问题。每个问题都遵循以问题为导向的方法，重点关注要解决的关键问题，明确定义已知和未知的内容，涵盖临床和实验室血液学实践和研究的范围。尽管邀请了大多数评论，但编辑欢迎潜在作者的建议。

The journal 'Best Practice and Research: Clinical Haematology' publishes articles that integrate the latest original research findings into practical, evidence-based reviews. These reviews aim to address key clinical issues in diagnosis, treatment, and patient management. Each issue follows a problem-oriented approach, focusing on critical questions that need to be addressed, clearly defining known and unknown aspects, and covering the scope of clinical and laboratory hematology practice and research. While most reviews are invited, the editors welcome suggestions from potential authors.

《Best Practice and Research: Clinical Haematology》期刊发表的文章将最新的原创研究成果整合成实用的、基于证据的评论。这些评论旨在解决诊断、治疗和患者管理中的关键临床问题。每期都采用以问题为导向的方法，重点关注需要解决的关键问题，明确已知与未知的内容，涵盖临床和实验室血液学的实践与研究。虽然大多数评论是邀请撰写的，编辑也欢迎潜在作者的建议。

Best Practice and Research: Clinical Haematology

Nodal marginal zone lymphoma: Clinical features, diagnosis, management and treatment

Nodular marginal zone lymphoma is a small B-cell lymphoma involving only lymph nodes and is the least common form of MZL constituting about 10% of cases, but has a less favorable prognosis than these two categories.

Category	Quartile
医学	4
医学, 血液学	4

Nodal marginal zone lymphoma: Clinical features, diagnosis, management and treatment

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