Interactions between heart rate (HR) and the Frank-Starling mechanism in augmenting cardiac output (CO) during acute volume loading were studied in dogs under varying conditions. In normal conscious dogs with low HRs of 70--90 beats/min, end-diastolic diameter (EDD) was maximal and CO was increased reflexly by cardioacceleration. By contrast, anesthetized open-chest dogs with high HRs ranging from 140 to 160 beats/min, responded with bradycardia and CO was adjusted solely by increasing stroke volume (SV). In anesthetized open-chest dogs with low HRs, EDD was less than maximal and increases in both HR and SV contributed to augment CO. These data show that both the cardioacceleration reflex and the Frank-Starling mechanism are important determinants of the cardiac response to elevated preload. Although the relative contribution of each control mechanism varies with initial conditions, their interplay extends the range of cardioregulation beyond that attainable by either loop operating alone.

G. E. Barnes

B. C. Chevis

H. J. Granger

AJP Regulatory Integrative and Comparative Physiology

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARISON PHYSIOLOGY 发表了原创研究，阐明了从分子到人类的各个层面的生理机制的正常或异常调节和整合，包括临床研究。重点领域包括对转基因动物的监管；模式生物；发育和组织可塑性；循环和高血压的神经体液控制；局部循环控制；心脏和肾脏整合；口渴和容量，电解质稳态；葡萄糖稳态和能量平衡；食欲和肥胖；炎症和细胞因子；妊娠-分娩-哺乳的综合生理学；以及对运动和环境压力的体温调节和适应。

The American Journal of Physiology - Regulatory Integrative and Comparative Physiology publishes original research that elucidates the normal and abnormal regulation and integration of physiological mechanisms across various levels, from molecules to humans, including clinical studies. Key areas of focus include the regulation of transgenic animals, model organisms, developmental and tissue plasticity, neurohumoral control of circulation and hypertension, local circulation control, integration of cardiac and renal functions, thirst and volume, electrolyte homeostasis, glucose homeostasis and energy balance, appetite and obesity, inflammation and cytokines, the integrative physiology of pregnancy, childbirth, and lactation, as well as thermoregulation and adaptation to exercise and environmental stress.

《American Journal of Physiology - Regulatory Integrative and Comparative Physiology》发表原创研究，阐明从分子到人类各个层面的生理机制的正常与异常调节和整合，包括临床研究。重点领域包括转基因动物的调控、模式生物、发育与组织可塑性、循环与高血压的神经体液控制、局部循环控制、心脏与肾脏的整合、口渴与容量、电解质稳态、葡萄糖稳态与能量平衡、食欲与肥胖、炎症与细胞因子、妊娠-分娩-哺乳的综合生理学，以及对运动与环境压力的体温调节与适应。

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Regulation of cardiac output during rapid volume loading

Data show that both the cardioacceleration reflex and the Frank-Starling mechanism are important determinants of the cardiac response to elevated preload and their interplay extends the range of cardioregulation beyond that attainable by either loop operating alone.

Category	Quartile
医学	3
医学, 生理学	3

Regulation of cardiac output during rapid volume loading

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