ABSTRACT Herein, the successful syntheses of D 3 ‐ and 13 C‐ N ‐methyl and D 9 ‐ tert‐ butyl Hoechst dyes are presented. This includes the preparation of the labelled D 3 ‐ and 13 C‐ N‐ methyl piperazines and D 9 ‐ tert ‐butylated hydroxytoluene precursors. The tert‐ butyl Hoechst dye is known to bind a specific RNA aptamer. Spectroscopic NMR studies of the labelled Hoechst dye‐aptamer complexes allowed for the unambiguous assignment of chemical shifts, as well as the dynamics of the bound dye.

Yulia A. Vlasenko

Avery J. To

Tess Fortier

Natasha M. Evans

Cole J. Lindsay

Peter J. Palermo

Thorsten Dieckmann

Graham K. Murphy

Journal of Labelled Compounds and Radiopharmaceuticals

《标记化合物和放射性药物杂志》发表了涉及标记化合物制备和这些化合物应用的研究的所有方面。这包括用于体外和体内医学、药理学、生物学、生化和化学研究的示踪方法。《标记化合物和放射性药物杂志》特别关注放射性药物的生物医学研究、诊断和治疗应用，涵盖从基础到发展的所有阶段基于物理和化学特征的分子结构、配位化合物和纳米粒子的代谢研究和技术开发到临床前和临床研究。

The Journal of Labelled Compounds and Radiopharmaceuticals publishes research covering all aspects of the preparation and application of labelled compounds. This includes tracing methods used in in vitro and in vivo medicine, pharmacology, biology, biochemistry, and chemical research. The journal places special emphasis on biomedical research involving radiopharmaceuticals, as well as their diagnostic and therapeutic applications, covering all stages from fundamental studies to preclinical and clinical research, focusing on the metabolic studies and technological developments of molecular structures, coordination compounds, and nanoparticles based on their physical and chemical characteristics.

《Journal of Labelled Compounds and Radiopharmaceuticals》发表涉及标记化合物制备及其应用的研究，涵盖所有相关领域。这些领域包括体外和体内医学、药理学、生物学、生化和化学研究中的示踪方法。该期刊特别关注放射性药物的生物医学研究及其在诊断和治疗中的应用，涵盖从基础研究到临床前和临床研究的各个阶段，涉及基于物理和化学特征的分子结构、配位化合物和纳米粒子的代谢研究与技术开发。

Category	Quartile
医学	4
医学, 生化研究方法	4
医学, 分析化学	4
医学, 药物化学	4

Synthesis and Application of D‐ and ¹³C‐Labelled tert‐Butyl Hoechst Dye

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Journal Info

Category	Quartile
CHEMISTRY, MEDICINAL	4

Synthesis and Application of D‐ and 13C‐Labelled tert‐Butyl Hoechst Dye

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Synthesis and Application of D‐ and ¹³C‐Labelled tert‐Butyl Hoechst Dye