Background and objectives Gangliosides (GAs) are important components of neural tissue and cell membrane. This study aims to investigate the association between toddlers' neurodevelopment, dietary GA intake, and serum GA concentration. Methods and study design A cross-sectional study was conducted in Beijing and Xuchang, Henan Province in China. 110 eligible healthy toddlers aged 24-48 months were recruited. Food frequency questionnaire (FFQ) and 24-h dietary recall were used to collect dietary information. Blood serum samples obtained from participants were used to perform GA composition analysis with high-performance liquid chromatographymass spectrometry (HPLC-MS). The neurodevelopment level was assessed with the Gesell Developmental Scale (GDS). Results Dietary ganglioside GD3, total GA, and seafood intake were identified to be associated with the gross motor developmental quotient (DQ). An inverse association was revealed between the fine motor DQ and fruit intake. No correlation was detected between serum GA concentration and DQ. Conclusions Dietary GA intake but not serum GA concentration is associated with neurodevelopment. Further prospective studies are needed to probe the relationships between the recommended dietary GA intake and toddlers.

Shengjie Tan

Ai Zhao

Jian Zhang

Pin Li

Chang Chen

Yumei Zhang

Asia Pacific Journal of Clinical Nutrition

《亚太临床营养学杂志》（APJCN）旨在发表高质量的临床营养相关研究成果，以培养该地区临床营养学家的能力，加强人类营养学和相关学科在健康促进和疾病预防方面的实践。 APJCN 将发表原创研究报告、评论、简短交流和案例报告。新闻、书评和其他项目也将包括在内。所有论文的接受标准是研究的质量和原创性及其对我们读者的意义。除非另有说明，稿件由至少两名匿名审稿人和编辑进行同行评审。编辑委员会保留拒绝任何材料发表的权利，并建议作者保留提交的手稿和信件的副本，因为材料不能退还。最终接受或拒绝取决于编辑委员会

The Asia Pacific Journal of Clinical Nutrition aims to publish high-quality research findings related to clinical nutrition, enhancing the capabilities of clinical nutritionists in the region and strengthening the practice of human nutrition and related disciplines in health promotion and disease prevention. The journal will publish original research articles, reviews, brief communications, and case reports, as well as news, book reviews, and other items. The acceptance criteria for all submissions are based on the quality and originality of the research and its significance to our readers. Unless otherwise stated, all manuscripts will undergo peer review by at least two anonymous reviewers and the editor. The editorial board reserves the right to reject any material for publication and advises authors to retain copies of submitted manuscripts and correspondence, as materials cannot be returned. The final decision on acceptance or rejection rests with the editorial board.

《亚太临床营养学杂志》（Asia Pacific Journal of Clinical Nutrition）旨在发表高质量的临床营养相关研究成果，以提升该地区临床营养学家的专业能力，并加强人类营养学及相关学科在健康促进和疾病预防方面的实践。该期刊将发表原创研究报告、评论、简短交流和案例报告，同时也会包括新闻、书评及其他相关内容。所有稿件的接受标准基于研究的质量、原创性及其对读者的意义。除非另有说明，所有稿件将由至少两名匿名审稿人和编辑进行同行评审。编辑委员会保留拒绝任何材料发表的权利，并建议作者保留提交的手稿和信件的副本，因为提交的材料将不予退还。最终的接受或拒绝决定由编辑委员会作出。

Category	Quartile
医学	4
医学, 营养学	4

Toddler neurodevelopment is associated with ganglioside intake but not serum ganglioside

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Journal Info

Category	Quartile
NUTRITION & DIETETICS	4