Blebs are known risk factors for intracranial aneurysm (IA) rupture. We analyzed differences between IAs that ruptured with blebs and those that ruptured without developing blebs to identify distinguishing characteristics among them and suggest possible mechanistic implications. Using image-based models, 25 hemodynamic and geometric parameters were compared between ruptured IAs with and without blebs (n = 673), stratified by location. Hemodynamic and geometric differences between bifurcation and sidewall aneurysms and for aneurysms at five locations were also analyzed. Ruptured aneurysms harboring blebs were exposed to higher flow conditions than aneurysms that ruptured without developing blebs, and this was consistent across locations. Bifurcation aneurysms were exposed to higher flow conditions than sidewall aneurysms. They had larger maximum wall shear stress (WSS), more concentrated WSS distribution, and larger numbers of critical points than sidewall aneurysms. Additionally, bifurcation aneurysms were larger, more elongated, and had more distorted shapes than sidewall aneurysms. Aneurysm morphology was associated with aneurysm location (p < 0.01). Flow conditions were different between aneurysm locations. Aneurysms at different locations are likely to develop into varying morphologies and thus be exposed to diverse flow conditions that may predispose them to follow distinct pathways towards rupture with or without bleb development. This could explain the diverse rupture rates and bleb presence in aneurysms at different locations.

Seyedeh Fatemeh Salimi Ashkezari

Fernando Mut

Anne M. Robertson

Juan R. Cebral

Cardiovascular Engineering and Technology

心血管工程与技术是一本出版心血管生理学和医学治疗各个方面的基础到转化研究的期刊。它是学术和工业研究人员传播利用工程原理和方法来推进与心血管系统相关的基础知识和技术解决方案的研究的论坛。邀请从亚细胞到系统级主题的手稿，包括但不限于植入式医疗设备、血液动力学和组织生物力学、功能成像、手术设备、电生理学、组织工程和再生医学、诊断仪器、生物制剂的运输和交付以及传感器.除了描述研究原始出版物的手稿外，还邀请审查这些主题的发展或其最新技术的手稿。

Cardiovascular Engineering and Technology is a journal that publishes research covering all aspects of cardiovascular physiology and medical treatments, focusing on both basic and translational studies. It serves as a forum for academic and industrial researchers to disseminate their work that utilizes engineering principles and methods to advance fundamental knowledge and technological solutions related to the cardiovascular system. The journal invites manuscripts on topics ranging from subcellular to system-level, including but not limited to implantable medical devices, hemodynamics, tissue biomechanics, functional imaging, surgical devices, electrophysiology, tissue engineering and regenerative medicine, diagnostic instruments, transport and delivery of biotherapeutics, and sensors. In addition to original research manuscripts, the journal also welcomes submissions that review developments in these areas or the latest technologies.

《Cardiovascular Engineering and Technology》是一本涵盖心血管生理学和医学治疗各个方面的期刊，致力于基础与转化研究的出版。它为学术界和工业界的研究人员提供了一个交流平台，旨在通过工程原理和方法推动与心血管系统相关的基础知识和技术解决方案的研究。期刊欢迎从亚细胞到系统级的各类手稿，主题包括但不限于植入式医疗设备、血液动力学、组织生物力学、功能成像、手术设备、电生理学、组织工程与再生医学、诊断仪器、生物制剂的运输与交付以及传感器。此外，期刊还邀请对这些主题的发展或最新技术进行审查的手稿。

Differences Between Ruptured Aneurysms With and Without Blebs: Mechanistic Implications

Aneurysms at different locations are likely to develop into varying morphologies and thus be exposed to diverse flow conditions that may predispose them to follow distinct pathways towards rupture with or without bleb development, which could explain the diverse rupture rates and bleb presence in aneurysms in different locations.

Category	Quartile
医学	4
医学, 心脏和心血管系统	4
医学, 工程生物医学	4

Differences Between Ruptured Aneurysms With and Without Blebs: Mechanistic Implications

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	4