Increased uric acid levels are associated with kidney dysfunction. We tested the hypothesis that uric acid level predicts future development of chronic kidney disease (CKD) in the general population.For this study, we enrolled 7,078 consecutive subjects with normal estimated glomerular filtration rates (eGFR; ≥60 ml/min/1.73 m(2)) who visited our hospital for a yearly health checkup (age: 52.8 ± 10.7 years; female: 35.8%). Subjects underwent a routine physical examination and laboratory assessment of cardiovascular disease risk factors at enrollment, and were followed up for 1,694 days (median) with the endpoint being the development of CKD (eGFR <60 ml/min/1.73 m(2)). The impact of uric acid and other cardiovascular risk factors at baseline on the future development of CKD were assessed.During the follow-up period, 417 male (9.2%) and 151 female subjects (6.0%) developed CKD. Univariate logistic regression analysis revealed a significant association between the onset of CKD and age, male gender, body mass index, blood pressure, fasting plasma glucose, dyslipidemia and uric acid. Multiple logistic regression analysis revealed that new-onset CKD was independently correlated with the baseline uric acid level after adjustment for possible factors. Subanalysis showed similar results in subjects with normal uric acid levels (male: ≤7.0 mg/dl; female: ≤6.0 mg/dl; n = 6,223).Uric acid is an independent predictor of future development of CKD. Whether preventing an increase in uric acid levels reduces the incidence of CKD must be clarified by prospective follow-up studies.

Hiroo Sonoda

Hiroyuki Takase

Yasuaki Dohi

Genjiro Kimura

American Journal of Nephrology

《美国肾脏病学杂志》是一份同行评审期刊，重点关注基础科学和临床研究中的及时主题。论文分为几个部分，包括：

The American Journal of Nephrology is a peer-reviewed academic journal that focuses on timely topics in basic science and clinical research. The articles are divided into several sections, including:

《美国肾脏病学杂志》是一份经过同行评审的学术期刊，专注于基础科学和临床研究中的重要主题。期刊中的论文分为多个部分，包括：

Uric Acid Levels Predict Future Development of Chronic Kidney Disease

Uric acid is an independent predictor of future development of chronic kidney disease (CKD) in the general population and whether preventing an increase in uric acid levels reduces the incidence of CKD must be clarified by prospective follow-up studies.

Category	Quartile
医学	3
医学, 泌尿学与肾脏学	2

Uric Acid Levels Predict Future Development of Chronic Kidney Disease

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Journal Info

Category	Quartile
UROLOGY & NEPHROLOGY	1