in addition to its roles as a physical barrier.Moreover, its abnormal changes like mutation, copy number alteration and mislocalization of molecules, have been associated with various pathologic conditions such as cancers, genetic disorders, and neurodegeneration [2][3][4][5][6].So, investigating its mechanism and disease-associated changes should be helpful for developing novel therapeutic strategies.These abnormal changes could be potential drug targets.Moreover, the necessity to deliver therapeutic DNA or proteins into the nucleus has arisen to treat diseases such as cancer and genetic diseases.Recent progresses in the research of the molecular mechanism for the nuclear transport via NPC, factors affecting the nuclear transport and the application for therapeutics will be summarized in this review. Nuclear Transport CycleTransportation of macromolecules including protein or RNAs between nucleoplasm and cytoplasm occurs through NPC in the nuclear envelope.NPC is highly selective and bidirectional transporter for various cargo molecules.There are four important factors for the nuclear transport: (1) nu-

Yun Hak Kim

Myoung-Eun Han

Sae-Ock Oh

Anatomy & Cell Biology

Anatomy and Cell Biology

The molecular mechanism for nuclear transport and its application

A review of recent progress in the research of the nuclear transportation (import and export) via nuclear pore complex and four important factors affecting nuclear transport (nucleoporins, Ran, karyopherins, and nuclear localization signals/nuclear export signals) will be discussed.

The molecular mechanism for nuclear transport and its application

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Journal Info

Category	Quartile
ANATOMY & MORPHOLOGY	3