Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus (HIV), has become a heavy burden of disease and an important public health problem in the world. Although current antiretroviral therapy (ART) is effective at suppressing the virus in the blood, HIV still remains in two different types of reservoirs-the latently infected cells (represented by CD4+ T cells) and the tissues containing those cells, which may block access to ART, HIV-neutralizing antibodies and latency-reversing agents. The latter is the focus of our review, as blood viral load drops below detectable levels after ART, a deeper and more systematic understanding of the HIV tissue reservoirs is imperative. In this review, we take the lymphoid system (including lymph nodes, gut-associated lymphoid tissue, spleen and bone marrow), nervous system, respiratory system, reproductive system (divided into male and female), urinary system as the order, focusing on the particularity and importance of each tissue in HIV infection, the infection target cell types of each tissue, the specific infection situation of each tissue quantified by HIV DNA or HIV RNA and the evidence of compartmentalization and pharmacokinetics. In summary, we found that the present state of HIV in different tissues has both similarities and differences. In the future, the therapeutic principle we need to follow is to respect the discrepancy on the basis of grasping the commonality. The measures taken to completely eliminate the virus in the whole body cannot be generalized. It is necessary to formulate personalized treatment strategies according to the different characteristics of the HIV in the various tissues, so as to realize the prospect of curing AIDS as soon as possible.

Kangpeng Li

Bo Liu

Rui Ma

Qiang Zhang

AIDS Patient Care and STDs

AIDS PATIENT CARE AND STDS 是最重要的期刊，提供旨在延长 HIV/AIDS 患者寿命和提高生活质量的诊断和治疗的最新发展和研究。该杂志提供关于 HIV/AIDS 和其他性传播感染的前沿临床、基础科学、社会学和基于行为的调查。临床试验、试点研究的定量和定性分析、综合评论和病例报告均来自世界各地的领先专家和科学家。艾滋病患者护理和 STD 覆盖范围包括：主要的艾滋病药物、疗法和抗逆转录病毒药物 HIV/AIDS 相关疾病、感染和并发症服药依从性的挑战当前的 HIV 预防技术其他 STD 治疗/预防方案的最新消息和进展，包括暴露前和暴露后预防

AIDS Patient Care and STDs is a significant journal dedicated to providing the latest developments and research in diagnostics and treatment aimed at extending the lifespan and improving the quality of life for HIV/AIDS patients. The journal covers cutting-edge clinical research, basic science, sociology, and behavioral studies related to HIV/AIDS and other sexually transmitted infections. Contributions include clinical trials, quantitative and qualitative analyses, comprehensive reviews, and case reports from leading experts and scientists worldwide. Topics addressed include major AIDS medications, therapies, antiretroviral drugs, HIV/AIDS-related diseases, infections and complications, challenges in medication adherence, current HIV prevention technologies, and the latest news and advancements in the treatment and prevention of other STDs, including pre-exposure and post-exposure prophylaxis.

《AIDS Patient Care and STDs》是一本重要的期刊，致力于提供关于延长HIV/AIDS患者寿命和提高生活质量的最新诊断和治疗研究。该期刊涵盖HIV/AIDS及其他性传播感染的前沿临床研究、基础科学、社会学和行为研究。文章包括来自全球领先专家和科学家的临床试验、定量和定性分析、综合评论和病例报告。内容涉及主要的艾滋病药物、疗法和抗逆转录病毒药物、HIV/AIDS相关疾病、感染和并发症、药物依从性挑战、当前HIV预防技术，以及其他性传播疾病的最新治疗和预防进展，包括暴露前和暴露后预防。

HIV Tissue Reservoirs: Current Advances in Research

It is found that the present state of HIV in different tissues has both similarities and differences, and it is necessary to formulate personalized treatment strategies according to the different characteristics of the HIV in the various tissues, so as to realize the prospect of curing AIDS as soon as possible.

Category	Quartile
医学	2
医学, 公共卫生、环境卫生与职业卫生	1
医学, 传染病学	2

HIV Tissue Reservoirs: Current Advances in Research

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Journal Info

Category	Quartile
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH	1