G proteins are a class of important signal transducers in mammalians. G proteins can corpoarated with G proteincoupled receptors (GPCRs) and transmit signals from extracellular stimuli into intracellular response, which will regulate a series of biological functions. G-proteins are heterotrimeric proteins composed of Gα, Gβ, and Gγ subunits. Based on structural and functional similarity of their α-subunits, G proteins are typically grouped into four classes (Gi, Gs, Gq/11, and G12/13). The Gq/11 subfamily consists of Gq, G11, G14, and G15/16 proteins. Gαq is the α-subunit of Gq protein and encoded by GNAQ. Our previous studies revealed that Gαq play an important role in regulating T cell survival and T cell differentiation. Inflammasomes are multiprotein complexes that play a critical role in modulating innate inflammatory response. NLRP3 inflammasome is currently the most extensively studied inflammasome.

Ruixue Kong

Lijun Peng

Honggang Bao

Lulu Sun

Yan Feng

Hua Li

Dashan Wang

Inflammation Research

INFLAMMATION RESEARCH (IR) 发表有关炎症和相关领域各个方面的同行评审论文，包括组织病理学、免疫学机制、基因表达、介质、实验模型、临床研究和药物效果。相关领域定义广泛，包括例如过敏和哮喘、休克、疼痛、关节损伤、皮肤病以及相关药物的临床试验。

The journal "Agents and Actions" publishes peer-reviewed papers on various aspects of inflammation and related fields, including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical research, and drug effects. The definition of related fields is broad, encompassing areas such as allergies and asthma, shock, pain, joint injuries, skin diseases, and clinical trials of related drugs.

《Agents and Actions》期刊发表关于炎症及相关领域的同行评审论文，涵盖组织病理学、免疫学机制、基因表达、介质、实验模型、临床研究和药物效果等多个方面。相关领域的定义广泛，包括过敏和哮喘、休克、疼痛、关节损伤、皮肤病以及相关药物的临床试验。

Category	Quartile
医学	3
医学, 细胞生物学	3
医学, 免疫学	3

The role of Gαq in regulating NLRP3 inflammasome activation

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