There is no consensus on how long antidementia medications should be administered to patients with Alzheimer disease (AD). To clarify this issue, we investigated the discontinuation of antidementia medications in Japanese home care settings, including community-dwelling and institutionalized patients. Using medical records from April 2017 to March 2022 at 3 clinics in Tokyo and Chiba prefectures, we selected patients with AD who started receiving home care medicine. Forty-nine patients discontinued antidementia medications during the observation period, there was no apparent deterioration in cognitive function or new occurrence of behavioral and psychological symptoms of dementia caused by the discontinuation of medications. More aggressive discontinuation of AD medications probably is recommended for patients with activities of daily living dysfunction, such as those receiving home care medicine.

Kiwami Kidana

Ryonosuke Yamaga

Hiroko Fujii

Masahiro Akishita

Takashi Yamanaka

Alzheimer Disease & Associated Disorders

​Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.

Alzheimer Disease and Associated Disorders is a peer-reviewed, multidisciplinary journal aimed at clinicians and researchers, with a primary focus on Alzheimer disease and associated disorders. The journal publishes original articles that emphasize research in humans, including epidemiological studies, clinical trials, experimental studies, and investigations into diagnosis and biomarkers, as well as research on the health of individuals with dementia and their caregivers. The scientific content of the journal is complemented by reviews of current literature, discussions of concepts, conjectures, and hypotheses related to dementia, brief reports, and letters to the editor.

《Alzheimer Disease and Associated Disorders》是一本经过同行评审的多学科期刊，面向临床医生和研究人员，主要关注阿尔茨海默病及其相关疾病。该期刊发表原创文章，强调对人类的研究，包括流行病学研究、临床试验和实验研究、诊断和生物标志物的研究，以及对痴呆症患者及其照顾者健康的研究。期刊的科学部分还包括对当前文献的综述、痴呆症相关的概念、推测和假设的讨论、简报和给编辑的信件。

Category	Quartile
医学	4
医学, 临床神经病学	4
医学, 病理学	4

Discontinuation of Alzheimer Disease Medications in Patients Receiving Home Care Medicine

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