Hemophagocytic lymphohistiocytosis (HLH) is a rare disease resulting from an abnormal proliferation of histiocytes within the body's tissues leading to an ineffective immune response. Typically, HLH is characterized by fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and hemophagocytosis. However, the premature infant with HLH may present differently making diagnosis of the disease cumbersome. If an infant is born with ascites, cytopenias, hypofibrinogenemia, and hepatosplenomegaly, a diagnosis of HLH cannot be ruled out. In addition, premature infants oftentimes will not present with fever because they are kept normothermic from ambient sources. Reports of premature infants with HLH in the literature are rare. This is a case presentation of a 27-week-gestation female with a family history of HLH.

Amanda G. Woods

Christopher W. Woods

Advances in Neonatal Care

ADVANCES IN NEONATAL CARE 对其发表的原创研究和临床实践文章采取了独特而动态的方法。解决每天面临的实践挑战——每年在二级和三级新生儿重症监护病房照顾 40,000 多名低出生体重婴儿——该杂志促进循证护理并改善最小患者及其家人的结果。同行评审的社论包括独特而详细的视觉和教学辅助工具，例如家庭教学工具箱、从研究到实践、培养临床专业知识和在线功能。每期都提供印刷和在线格式的继续教育 (CE) 文章。

Advances in Neonatal Care takes a unique and dynamic approach to publishing original research and clinical practice articles. The journal addresses the daily practical challenges faced in neonatal intensive care units, caring for over 40,000 low birth weight infants each year. By promoting evidence-based care, it aims to improve outcomes for these vulnerable patients and their families. Peer-reviewed editorials include unique and detailed visual and educational aids, such as family teaching toolkits, translation from research to practice, development of clinical expertise, and online features. Each issue provides continuing education (CE) articles in both print and online formats.

《Advances in Neonatal Care》采用独特而动态的方法，发表原创研究和临床实践文章。该杂志专注于解决新生儿重症监护病房中每天面临的实践挑战，每年照顾超过40,000名低出生体重婴儿。通过促进循证护理，该杂志致力于改善这些脆弱患者及其家庭的结果。同行评审的社论中包含独特而详细的视觉和教学辅助工具，例如家庭教学工具箱、从研究到实践的转化、临床专业知识的培养以及在线功能。每期杂志还提供印刷和在线格式的继续教育（CE）文章。

Hemophagocytic Lymphohistiocytosis in the Premature Neonate

This is a case presentation of a 27-week-gestation female with a family history of HLH, a rare disease resulting from an abnormal proliferation of histiocytes within the body's tissues leading to an ineffective immune response.

Category	Quartile
医学	4
医学, 护理	3

Hemophagocytic Lymphohistiocytosis in the Premature Neonate

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