Nicotinamide N-methyltransferase (NNMT) has been proposed as a link between the environmental and genetic factors of Parkinson disease (PD). Therefore, we explored the hypothesis that high levels of NNMT expression may predispose to the development of PD. Regions of high mRNA expression were shown in the spinal cord, medulla, and temporal lobe, with lowest expression in the cerebellum, subthalamic nucleus, and caudate nucleus. Using 2 NNMT antibodies, the protein was shown to be expressed in multipolar neurons in the temporal lobe, caudate nucleus, and spinal cord, granular neurons of the cerebellum, dopaminergic neurons in the substantia nigra, and in the axons of the third nerve. Expression of NNMT was compared in PD and non-PD control cerebella and caudate nucleus. PD tissue exhibited significantly increased levels of NNMT protein and activity. PD disease duration was inversely correlated with the level of expression in cerebellum. This is the first demonstration that patients with PD have higher levels of NNMT activity and protein in brain tissue than those without PD and that NNMT expression is associated with neurons that degenerate in PD.

Richard B. Parsons

Marie-Louise Smith

Adrian C. Williams

Rosemary H. Waring

David B. Ramsden

Journal of Neuropathology & Experimental Neurology

JOURNAL OF NEUROPATHOLOGY & EXPERIMENTAL NEUROLOGY 是美国神经病理学家协会 (AANP) 的官方期刊。该杂志发表关于神经病理学和实验神经科学的同行评审研究、书评、信件和协会新闻，涵盖基础神经科学的广泛领域，重点是人类神经系统疾病。它由来自世界各地的神经病理学家、神经学家、神经外科医生、病理学家、精神病学家和基础神经科学家编写，并为它们编写。自 1942 年以来一直连续出版。

The Journal of Neuropathology and Experimental Neurology is the official journal of the American Association of Neuropathologists (AANP). This journal publishes peer-reviewed research, book reviews, letters, and association news related to neuropathology and experimental neuroscience, covering a wide range of areas in basic neuroscience with a focus on human neurological diseases. It has been continuously published since 1942, featuring contributions from neuropathologists, neurologists, neurosurgeons, pathologists, psychiatrists, and basic neuroscientists from around the world.

《Journal of Neuropathology and Experimental Neurology》是美国神经病理学家协会（AANP）的官方期刊。该期刊发表关于神经病理学和实验神经科学的同行评审研究、书评、信件和协会新闻，涵盖基础神经科学的广泛领域，特别关注人类神经系统疾病。自1942年以来，该期刊一直持续出版，作者包括来自世界各地的神经病理学家、神经学家、神经外科医生、病理学家、精神病学家和基础神经科学家。

Journal of Neuropathology and Experimental Neurology

Expression of Nicotinamide N-Methyltransferase (E.C. 2.1.1.1) in the Parkinsonian Brain

This is the first demonstration that patients with PD have higher levels of NNMT activity and protein in brain tissue than those without PD and that NN MT expression is associated with neurons that degenerate in PD.

Category	Quartile
医学	3
医学, 病理学	3
医学, 临床神经病学	4
医学, 神经科学	4

Expression of Nicotinamide N-Methyltransferase (E.C. 2.1.1.1) in the Parkinsonian Brain

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