Glycosylation is a complex co-translational and post-translational modification (PTM) in eukaryotes that utilizes glycosyltransferases to generate a vast array of glycoconjugate structures. Recent studies have highlighted the role of glycans in regulating essential molecular, cellular, tissue, organ, and systemic biological processes with significant implications for human diseases, particularly cancer. The metabolic reliance of cancer, spanning tumor initiation, disease progression, and resistance to therapy, necessitates a range of uniquely altered cellular metabolic pathways. In addition, the intricate interplay between cell-intrinsic and -extrinsic mechanisms is exemplified by the communication between cancer cells, cancer stem cells (CSCs), cancer-associated fibroblasts (CAFs), and immune cells within the tumor microenvironment (TME). In this review article, we explore how differential glycosylation in cancer influences the metabolism and stemness features alongside new avenues in glycobiology.

Venkatesh Varadharaj

Wyatt Petersen

Surinder K Batra

Moorthy P Ponnusamy

Trends in Cell Biology

TRENDS IN CELL BIOLOGY 是分子和细胞生物学领域领先的评论期刊之一。每月发表的评论文章监控当前细胞生物学研究的广度和深度，及时报告新的发展，整合方法、学科和原则。所有文章均由顶尖科学家委托，然后经过严格的同行评审，确保平衡和准确性。除了评论之外，TRENDS IN CELL BIOLOGY 还发表意见文章，这些文章跟踪趋势并提供创新想法，以洞察新发展的影响并提出未来方向。

Trends in Cell Biology is one of the leading review journals in the field of molecular and cell biology. The journal publishes monthly review articles that monitor the breadth and depth of current research in cell biology, reporting new developments in a timely manner and integrating methods, disciplines, and principles. All articles are commissioned by top scientists and undergo rigorous peer review to ensure balance and accuracy. In addition to review articles, Trends in Cell Biology also publishes opinion pieces that track trends and provide innovative ideas to insightfully assess the impact of new developments and suggest future directions.

《Trends in Cell Biology》是分子和细胞生物学领域领先的评论期刊之一。该期刊每月发表的评论文章监测当前细胞生物学研究的广度和深度，及时报道新的发展，整合方法、学科和原则。所有文章均由顶尖科学家委托，并经过严格的同行评审，以确保内容的平衡和准确性。除了评论文章外，《Trends in Cell Biology》还发表意见文章，这些文章跟踪趋势并提供创新想法，以洞察新发展的影响并提出未来的研究方向。

Category	Quartile
生物学	1
生物学, 细胞生物学	2

Sugar symphony: glycosylation in cancer metabolism and stemness

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