Abstract Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long‐term clinical deployment. The FBR is an inevitable immunological reaction to IMDs, resulting in inflammation and subsequent fibrotic encapsulation. Excessive fibrosis may impair IMDs function, eventually necessitating retrieval or replacement for continued therapy. Therefore, understanding the implant design parameters and their degree of influence on FBR is pivotal to effective and long lasting IMDs. This review gives an overview of FBR as well as anti‐FBR strategies. Furthermore, we highlight recent advances in biomimetic approaches to resist FBR, focusing on their characteristics and potential biomedical applications.

Simone Capuani

Gulsah Malgir

Corrine Ying Xuan Chua

Alessandro Grattoni

Bioengineering & Translational Medicine

Bioengineering and Translational Medicine

Advanced strategies to thwart foreign body response to implantable devices

This review gives an overview of FBR as well as anti‐FBR strategies, and highlights recent advances in biomimetic approaches to resist FBR, focusing on their characteristics and potential biomedical applications.

Category	Quartile
医学	2
医学, 工程生物医学	2

Advanced strategies to thwart foreign body response to implantable devices

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	1