Reactive Oxygen Species (ROS) refers to the highly reactive substances which contain oxygen radicals. Hypochlorous acid, peroxides, superoxide, singlet oxygen, alpha-oxygen, and hydroxyl radicals are the major examples of ROS. Generally, the reduction of oxygen (O2) in molecular form produces superoxide (•O2 -) anion. ROS are produced during a variety of biochemical reactions within the cell organelles, such as endoplasmic reticulum, mitochondria, and peroxisome. Naturally, ROS are also formed as a byproduct of the normal metabolism of oxygen. The production of ROS can be induced by various factors such as heavy metals, tobacco, smoke, drugs, xenobiotics, pollutants, and radiation. From various experimental studies, it is reported that ROS acts as either a tumor-suppressing or a tumor-promoting agent. The elevated level of ROS can arrest the growth of tumors through the persistent increase in cell cycle inhibition. The increased level of ROS can induce apoptosis by both intrinsic and extrinsic pathways. ROS is considered to be a tumor-suppressing agent as the production of ROS is due to the use of most of the chemotherapeutic agents in order to activate cell death. The cytotoxic effect of ROS provides impetus towards apoptosis, but in higher levels, ROS can cause initiation of malignancy that leads to uncontrolled cell death in cancer cells. In contrast, some species of ROS can influence various activities at the cellular level, including cell proliferation. This review highlights the genesis of ROS within cells by various routes and their role in cancer therapies.

Biswa Mohan Sahoo

Bimal Krishna Banik

Preetismita Borah

Adya Jain

Anti-Cancer Agents in Medicinal Chemistry

原：CURRENT MEDICINAL CHEMISTRY - ANTI-CANCER AGENTS由该领域的领导者撰写的深入评论和客座编辑的问题，涵盖了癌症药物化学的一系列当前主题。该杂志只考虑发表高质量的研究论文。ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 是每一位希望随时了解癌症药物发现最新和最重要进展的药物化学家的重要期刊。

Anti-Cancer Agents in Medicinal Chemistry is a journal authored by leaders in the field, offering in-depth reviews and guest-edited issues that cover a range of current topics in cancer medicinal chemistry. The journal only considers high-quality research papers for publication, making it an essential resource for medicinal chemists who wish to stay informed about the latest and most significant advancements in cancer drug discovery.

《Anti-Cancer Agents in Medicinal Chemistry》是一本由该领域的领导者撰写的期刊，提供深入的评论和特邀编辑的专题，涵盖癌症药物化学的多个当前主题。该杂志只考虑发表高质量的研究论文，是每位希望了解癌症药物发现最新进展的药物化学家的重要参考。

Reactive Oxygen Species (ROS): Key Components in Cancer Therapies

The cytotoxic effect of ROS provides impetus towards apoptosis, but in higher levels, ROS can cause initiation of malignancy that leads to uncontrolled cell death in cancer cells.

Category	Quartile
医学	4
医学, 药物化学	4
医学, 肿瘤学	4

Reactive Oxygen Species (ROS): Key Components in Cancer Therapies

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