We recently described the synthesis and antiviral activity of the compounds 5-phenyl-3-(4-cyano-5-phenylisothiazol-3-yl) disulphanyl-4-isothiazolecarbonitrile and S-(4-cyano-5-phenylisothiazol -3-yl)-O-ethyl thiocarbonate, which were found to be effective against both HIV-1 (IIIB) and HIV-2 (ROD). We have now evaluated these compounds against both RNA and DNA viruses, obtaining high selectivity indexes for poliovirus 1 (SI: 223 and 828, respectively) and Echovirus 9 (SI: 334 and 200, respectively). In our previous studies, 3-methylthio-5-(4-OBn-phenyl)-4-isothiazolecarbonitrile was found to exhibit a broad spectrum of action against picornaviruses, we therefore selected this compound and S-(4-cyano-5-phenylisothiazol-3-yl)-O-ethyl thiocarbonate as the model for the synthesis of a new isothiazole derivative, S-[4-cyano-5-(4-OBn-phenyl)isothiazol-3-yl]-O-ethyl thiocarbonate. This compound was evaluated against picornaviruses, measles virus, HIV-1 (IIIB) and HIV-2 (ROD), and some DNA viruses (adenovirus type 2 and herpes simplex virus type 1). The compound was shown to be active against rhinoviruses 2, 39, 86 and 89, Coxsackie B1 and measles virus.

Adriana Garozzo

Christian CC Cutri

Christophe Pannecouque

Angelo Castro

Francesco Guerrera

Erik De Clercq

Antiviral chemistry & chemotherapy

Antiviral Chemistry & Chemotherapy publishes the results of original research concerned with the biochemistry, mode of action, chemistry, pharmacology and virology of antiviral compounds. Manuscripts dealing with molecular biology, animal models and vaccines are welcome.     The journal also publishes reviews, pointers, short communications and correspondence.

Antiviral Chemistry and Chemotherapy publishes original research results related to the biochemistry, mode of action, chemistry, pharmacology, and virology of antiviral compounds. Manuscripts addressing molecular biology, animal models, and vaccines are also welcome. The journal additionally publishes reviews, pointers, short communications, and correspondence.

《Antiviral Chemistry and Chemotherapy》期刊致力于发表与抗病毒化合物的生物化学、作用机制、化学、药理学和病毒学相关的原创研究成果。欢迎提交涉及分子生物学、动物模型和疫苗的手稿。此外，期刊还接受综述、指引、简短通讯和信函的投稿。

Antiviral Chemistry and Chemotherapy

Isothiazole Derivatives as Antiviral Agents

This compound was evaluated against picornaviruses, measles virus, HIV-1 (IIIB) and HIV-2 (ROD), and some DNA viruses and was shown to be active against rhinoviruses 2, 39, 86 and 89, Coxsackie B1 and measles virus.

Isothiazole Derivatives as Antiviral Agents

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