Context Oxidative stress is an important factor for vitreomacular interface disease development in a theoretical model. Purpose The aim of the study was to evaluate the correlation between oxidative stress in the human epiretinal membrane (ERM) and retinal morphological changes. Material and methods The study included patients scheduled for vitrectomy with epiretinal membrane removal. LogMAR best corrected visual acuity was assessed and optical coherence tomography was performed. Patients were divided into three groups: Type 1 – epiretinal membrane with premacular fibrosis; type 2 – epiretinal membrane with co-existing layer hole; and type 3 – ERM with co-existing full-thickness macular hole. During vitrectomy, epiretinal membranes were collected. Total oxidant status was determined by an automated colorimetric method in homogenates of epiretinal membrane. Statistical analysis The Mann-Whitney U test, Kruskal-Wallis test and Spearman linear correlation analysis were used. Statistical significance was set with a level of α = 0.05. Results Twenty-one Caucasian women (60%) and 14 men (40%) were included in the study. The average age of participants was 74.7 years (95% CI: 71.13–75.45). The mean best corrected visual acuity LogMAR value in the group was 0.8 (95% CI: 0.9–0.7). The mean ratio of total oxidant status to protein level in the collected samples was 0.161 (95% CI: 0.08–0.23) µmol/mg of protein. No correlation was found between total oxidant status and the degree of morphological retinal changes. Conclusion The study found no significant correlation between the level of oxidative stress in epiretinal membrane and retinal morphological changes.

Tomasz Wilczyński

Jolanta Zalejska-Fiolka

Sabina Sapeta-Wieckowska

Monika Sarnat-Kucharczyk

Wojciech Rokicki

Acta Biochimica Polonica

ACTA BIOCHIMICA POLONICA 是一本涵盖酶学和代谢、膜和生物能量学、基因结构和表达、蛋白质、核酸和碳水化合物结构和代谢的期刊。

Acta Biochimica Polonica is a professional journal that covers enzymology, metabolism, membrane biology and bioenergetics, gene structure and expression, as well as the structure and metabolism of proteins, nucleic acids, and carbohydrates.

《Acta Biochimica Polonica》是一本涵盖酶学、代谢、膜生物学和生物能量学、基因结构与表达、以及蛋白质、核酸和碳水化合物的结构与代谢的专业期刊。

Category	Quartile
生物学	4
生物学, 生化与分子生物学	4

In situ oxidative stress in patients with epiretinal membrane

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Journal Info

Category	Quartile
BIOCHEMISTRY & MOLECULAR BIOLOGY	4