Chronic diarrhea is a significant challenge in clinical practice because of its high prevalence and various causes. Comprehensive clinical assessment and stepwise laboratory approach are crucial for an accurate diagnosis. This report presents a case of an adult woman who experienced chronic watery diarrhea, complicated by renal impairment and multiple electrolyte imbalances, including hypokalemia, hypophosphatemia, and metabolic acidosis. The diagnosis of a vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases was confirmed by elevated serum levels of a vasoactive intestinal polypeptide (VIP) and imaging findings of a pancreatic mass with multiple hepatic lesions. Preoperative management, including fluid rehydration, electrolyte correction, and somatostatin analog therapy, significantly improved her clinical symptoms. Subsequent surgical tumor removal and radiofrequency ablation of the hepatic lesions resulted in complete resolution of symptoms and normalized VIP levels. This case emphasizes the importance of early recognition of this rare tumor in patients with chronic diarrhea to improve clinical outcomes.

Sutharin Suteetorn

Krit Kitisin

Natcha Wanpiyarat

Supaksorn Kunjan

Thiti Snabboon

Acta Medica (Hradec Kralove Czech Republic)

Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."

Acta Medica is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové, under the Karolinum Press of Charles University. The journal is peer-reviewed and published quarterly in both print and electronic formats. The language of Acta Medica is English, and it includes review articles, original research, brief communications, case reports, announcements, and notices. Founded in 1958, it was originally titled 'A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove.'

《Acta Medica》是由捷克赫拉德茨-克拉洛韦医学院出版的多学科医学期刊，出版单位为查理大学的Karolinum出版社。该期刊经过同行评审，每季度出版一次，提供纸质和电子版。期刊语言为英语，内容包括综述文章、原创研究、简报、病例报告、公告和通知。该期刊创办于1958年，最初名为《查理大学医学院科学著作集》。

VIPoma: An Unusual Cause of Chronic Diarrhea

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