Prion diseases are a group of animal and human neurodegenerative, albeit transmissible diseases. The lack of effective preventive and therapeutic approaches represents a serious problem in their management. This is especially true for those prion diseases of animals which behave like infectious and contagious diseases. In the case of sheep scrapie, the well- known role of variations in the prion protein gene (PRNP) in conferring resistance/susceptibility represents an opportunity which has been exploited to select populations genetically resistant to the disease. The recent description of Camel prion disease (CPrD) in Algeria and Tunisia and the suspicion falling into the category of infectious prion diseases, make urgent to investigate the possible existence of genetic determinants useful for its control. Herein, we investigated PRNP variability in 232 animals from six dromedary populations (Azawad, Hybrid, Naili, Rguibi, Sahraoui, Targui) in Algeria. A Gly69Ser mutation was observed in a single animal of the Targui population and a Gly134Glu polymorphism in the Azawad, Hybrid and Rguibi populations, with a frequency of the 134Glu allele of 2.6%, 7.7% and 7.1%, respectively. Although our work highlights a low variability of Algerian dromedary PRNP, as a possible indication of a recent evolutionary history of CPrD, it offers also evidence of PRNP variants whose role in prion disease resistance/susceptibility deserve to be deepened.

Kaouadji Zoubeyda

Meghelli Imane

Cherifi Youcef

Babelhadj Baaissa

Gaouar S.B. Suheil

Conte Michela

Capocefalo Antonio

Agrimi Umberto

Chiappini Barbara

Vaccari Gabriele

Animal Gene

Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.    Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include:    DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA).  Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation)  Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation).  Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.)  Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks.  Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics.  Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.

The journal "Animal Gene" publishes research papers focusing on the regulation, expression, function, and evolution of genes across various biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. We aim to be a diverse journal that welcomes submissions from all fields. Some key areas of research include: \n\n1. DNA Organization, Replication & Evolution: Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA).\n\n2. Expression & Function: Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation).\n\n3. Regulation: Focus on processes that mediate gene expression (epigenetics, chromatin, histone code, transcription, translation, protein degradation).\n\n4. Cell Signaling: Focus on mechanisms that control information flow into the nucleus to regulate gene expression (kinase and phosphatase pathways controlled by extracellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs, etc.).\n\n5. Profiling of Gene Expression and Genetic Variation: Focus on high-throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways, and protein/protein networks.\n\n6. Genetics: Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics.\n\n7. Molecular Pathology & Regenerative Medicine: Focus on the deregulation of molecular processes in human diseases and the mechanisms supporting tissue regeneration through pluripotent or multipotent stem cells.

《Animal Gene》期刊致力于发表关于基因在各种生物背景下的调控、表达、功能和进化的研究论文，涵盖所有原核生物和真核生物以及病毒。我们期望成为一个多样化的期刊，欢迎各个领域的主题投稿。以下是一些主要研究方向：\n\n1. DNA的组织、复制与进化：关注基因组DNA（染色体组织、比较基因组学、DNA复制、DNA修复、移动DNA、线粒体DNA、叶绿体DNA）。\n\n2. 表达与功能：关注功能性RNA（微RNA、转运RNA、核糖体RNA、mRNA剪接、替代多腺苷酸化）。\n\n3. 调控：关注介导基因表达的过程（表观遗传学、染色质、组蛋白代码、转录、翻译、蛋白质降解）。\n\n4. 细胞信号传导：关注控制信息流入细胞核以调控基因表达的机制（由细胞外配体控制的激酶和磷酸酶通路、Wnt、Notch、TGFbeta/BMPs、FGFs、IGFs等）。\n\n5. 基因表达和遗传变异的分析：关注高通量方法（如DeepSeq、ChIP-Seq、Affymetrix微阵列、蛋白质组学）来定义基因调控电路、分子通路和蛋白质/蛋白质网络。\n\n6. 遗传学：关注模式生物（如小鼠、青蛙、果蝇、线虫）中的发育、人类遗传变异、群体遗传学，以及农业和兽医学遗传学。\n\n7. 分子病理学与再生医学：关注人类疾病中分子过程的失调及通过多能或多潜能干细胞支持组织再生的机制。

Variability of the prion protein gene (PRNP) in Algerian dromedary populations

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