The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. The mGluRs bind glutamate within a large extracellular domain and transmit signals through the receptor protein to intracellular signaling partners. A great deal of progress has been made in determining the mechanisms by which mGluRs are activated, proteins with which they interact, and orthosteric and allosteric ligands that can modulate receptor activity. The widespread expression of mGluRs makes these receptors particularly attractive drug targets, and recent studies continue to validate the therapeutic utility of mGluR ligands in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's disease, anxiety, depression, and schizophrenia.

Colleen M. Niswender

P. Jeffrey Conn

The Annual Review of Pharmacology and Toxicology

自 1961 年出版的《药理学和毒理学年度评论》涵盖了药理学和毒理学领域的重大发展，包括受体、转运蛋白、酶和化学试剂；药物开发科学；免疫系统、中枢和自主神经系统、胃肠系统、心血管系统、内分泌系统和肺系统等系统；和专题。

The Annual Review of Pharmacology and Toxicology, published since 1961, covers significant developments in the fields of pharmacology and toxicology, including research on receptors, transport proteins, enzymes, and chemical agents; the science of drug development; and topics related to various systems such as the immune system, central and autonomic nervous systems, gastrointestinal system, cardiovascular system, endocrine system, and pulmonary system.

《Annual Review of Pharmacology and Toxicology》自1961年出版，涵盖了药理学和毒理学领域的重要进展，包括受体、转运蛋白、酶和化学试剂的研究；药物开发的科学；以及免疫系统、中枢神经系统、自主神经系统、胃肠系统、心血管系统、内分泌系统和肺系统等多个系统的相关内容。

Annual Review of Pharmacology and Toxicology

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

The widespread expression of mGluRs makes these receptors particularly attractive drug targets, and recent studies continue to validate the therapeutic utility of m GluR ligands in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's Disease, anxiety, depression, and schizophrenia.

Category	Quartile
医学	1
医学, 药学	1
医学, 毒理学	1

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info