Sleep maintains the function of the entire body through homeostasis. Chronic sleep deprivation (CSD) is a prime health concern in the modern world. Previous reports have shown that CSD has profound negative effects on brain vasculature at both the cellular and molecular levels, and that this is a major cause of cognitive dysfunction and early vascular ageing. However, correlations among sleep deprivation (SD), brain vascular changes and ageing have barely been looked into. This review attempts to correlate the alterations in the levels of major neurotransmitters (acetylcholine, adrenaline, GABA and glutamate) and signalling molecules (Sirt1, PGC1α, FOXO, P66shc, PARP1) in SD and changes in brain vasculature, cognitive dysfunction and early ageing. It also aims to connect SD-induced loss in the number of dendritic spines and their effects on alterations in synaptic plasticity, cognitive disabilities and early vascular ageing based on data available in scientific literature. To the best of our knowledge, this is the first article providing a pathophysiological basis to link SD to brain vascular ageing.

Arehally M. Mahalakshmi

Bipul Ray

Sunanda Tuladhar

Abid Bhat

Muhammed Bishir

Srinivasa Rao Bolla

Jian Yang

Musthafa Mohamed Essa

Saravana Babu Chidambaram

Gilles J. Guillemin

Meena Kishore Sakharkar

GeroScience

GEROSCIENCE 是一份双月刊、国际同行评审期刊，发表与衰老生物学研究和影响衰老的生物医学应用研究相关的文章。要考虑的文章范围包括进化生物学、生物物理学、遗传学、基因组学、蛋白质组学、分子生物学、细胞生物学、生物化学、内分泌学、免疫学、生理学、药理学、神经科学和心理学。

GeroScience is a bi-monthly international peer-reviewed journal that focuses on research in the biology of aging and biomedical applications related to aging. The scope of articles considered includes evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, and psychology.

GEROSCIENCE 是一本双月刊的国际同行评审期刊，专注于衰老生物学及其相关的生物医学应用研究。期刊接受的文章范围广泛，包括进化生物学、生物物理学、遗传学、基因组学、蛋白质组学、分子生物学、细胞生物学、生物化学、内分泌学、免疫学、生理学、药理学、神经科学和心理学等领域。

Sleep, brain vascular health and ageing

This is the first article providing a pathophysiological basis to link SD to brain vascular ageing and aims to connect SD-induced loss in the number of dendritic spines and their effects on alterations in synaptic plasticity, cognitive disabilities and early vascular ageing.

Category	Quartile
医学	2
医学, 老年医学	2

Sleep, brain vascular health and ageing

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Journal Info

Category	Quartile
GERIATRICS & GERONTOLOGY	1