Neuromyelitis optica (NMO), formerly known as Devic disease, is an autoimmune astrocytopathic disease characterized by transverse myelitis and optic neuritis. Most patients demonstrate a relapsing course with incomplete recovery between attacks, resulting in progressive disability. The pathogenesis involves production of aquaporin-4 antibodies (AQP4-IgG) by plasmablasts in peripheral circulation, disruption of the blood-brain barrier, complement-mediated astrocyte injury, and secondary demyelination. The diagnosis relies on characteristic clinical manifestations in the presence of serum AQP4-IgG positivity or specific neuroimaging findings, and exclusion of alternative etiologies. Current treatment involves aggressive immunosuppression with pulse-dose steroids during acute attacks and long-term immunosuppression for attack prevention.

Sarah L Patterson

Sarah E Goglin

Rheumatic Disease Clinics of North America

风湿病诊所为您更新患者管理的最新趋势，让您了解最新进展，并为选择治疗方案提供良好的基础。每期（2 月、5 月、8 月和 11 月）都侧重于风湿病学的一个主题，并在经验丰富的编辑的指导下呈现。主题包括骨关节炎、类风湿性关节炎、晶体疾病、MSK 检查、骨骼疾病、免疫缺陷状态、狼疮、神经肌肉疾病、疼痛疾病、硬皮病、血管炎、儿科、疗法、治疗指南和治疗方式。

The Rheumatic Disease Clinics of North America aims to provide you with the latest trends and advancements in the management of rheumatic disease patients, helping you establish a solid foundation for treatment options. Each issue (February, May, August, and November) focuses on a specific theme in rheumatology, curated by an experienced editorial team. Topics include osteoarthritis, rheumatoid arthritis, crystal diseases, musculoskeletal examinations, bone diseases, immunodeficiency states, lupus, neuromuscular diseases, pain disorders, scleroderma, vasculitis, pediatrics, therapies, treatment guidelines, and treatment modalities.

《Rheumatic Disease Clinics of North America》致力于为您提供风湿病患者管理的最新趋势和进展，帮助您为治疗方案的选择打下坚实的基础。每期（2月、5月、8月和11月）聚焦于风湿病学的一个特定主题，内容由经验丰富的编辑团队精心编排。主题涵盖骨关节炎、类风湿性关节炎、晶体疾病、肌肉骨骼检查、骨骼疾病、免疫缺陷状态、狼疮、神经肌肉疾病、疼痛疾病、硬皮病、血管炎、儿科、疗法、治疗指南和治疗方式等。

Neuromyelitis Optica

Neuromyelitis optica (NMO), formerly known as Devic disease, is an autoimmune astrocytopathic disease characterized by transverse myelitis and optic neuritis that shows a relapsing course with incomplete recovery between attacks, resulting in progressive disability.

Category	Quartile
医学	4
医学, 风湿病学	4

Neuromyelitis Optica

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