Epigenetic mechanisms contribute to the establishment and maintenance of cell-type-specific gene expression patterns. In this review, we focus on the functions of histone lysine methylation in the context of epigenetic gene regulation during developmental transitions. Over the past few years, analysis of histone lysine methylation in active and repressive nuclear compartments and, more recently, genome-wide profiling of histone lysine methylation in different cell types have revealed correlations between particular modifications and the transcriptional status of genes. Identification of histone methyltransferases (HMTases) and specific binding factors for most methylated lysine positions has provided a novel insight into the mechanisms of epigenetic gene regulation. In addition, analyses of HMTase knockout mice show that histone lysine methylation has important functions for normal development. In this study, we review mechanisms of gene activation and repression by histone lysine methylation and discuss them in the context of the developmental roles of HMTases.

S Dambacher

M Hahn

G Schotta

Heredity

遗传是遗传学会的官方期刊。它涵盖了遗传学领域的广泛主题，因此论文必须解决期刊广泛读者感兴趣的概念或应用问题

Heredity is the official journal of the Genetics Society. It covers a wide range of topics in the field of genetics, and papers must address concepts or application issues that are of interest to a broad readership.

《Heredity》是遗传学会的官方期刊，涵盖遗传学领域的广泛主题。期刊所发表的论文需解决与遗传学相关的概念或应用问题，以吸引广泛的读者群体。

Epigenetic regulation of development by histone lysine methylation

Mechanisms of gene activation and repression by histone lysine methylation are reviewed and discussed in the context of the developmental roles of HMTases and analyses of H MTase knockout mice show that hist one lysines methylation has important functions for normal development.

Category	Quartile
生物学	2
生物学, 遗传学	2
生物学, 生态学	3
生物学, 进化生物学	3

Epigenetic regulation of development by histone lysine methylation

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Journal Info

Category	Quartile
GENETICS & HEREDITY	2