Endocrine disrupting chemicals (EDCs) are compounds that alter the structure and function of the endocrine system and may be contributing to disorders of the reproductive, metabolic, neuroendocrine and other complex systems. Typically, these outcomes cannot be modeled in cell-based or other simple systems necessitating the use of animal testing. Appropriate animal model selection is required to effectively recapitulate the human experience, including relevant dosing and windows of exposure, and ensure translational utility and reproducibility. While classical toxicology heavily relies on inbred rats and mice, and focuses on apical endpoints such as tumor formation or birth defects, EDC researchers have used a greater diversity of species to effectively model more subtle but significant outcomes such as changes in pubertal timing, mammary gland development, and social behaviors. Advances in genomics, neuroimaging and other tools are making a wider range of animal models more widely available to EDC researchers.

Heather B. Patisaul

Suzanne E. Fenton

David Aylor

Best Practice & Research Clinical Endocrinology & Metabolism

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM 是一本专题系列出版物，将最新原创研究的结果整合到实用的、基于证据的评论文章中，旨在解决诊断、治疗和患者管理等关键临床问题。每个问题都遵循一个问题- 面向方法，侧重于要解决的关键问题，明确定义已知内容并突出未来研究的主题。管理是用实际术语描述的，以便它可以应用于个体患者。该系列针对在实践中或培训中的医生。

Best Practice and Research: Clinical Endocrinology and Metabolism is a specialized series that integrates the latest original research findings into practical, evidence-based review articles aimed at addressing key clinical issues such as diagnosis, treatment, and patient management. Each issue follows a thematic approach, focusing on critical questions that need to be addressed, clearly defining known information, and highlighting future research directions. Management strategies are described in practical terms to facilitate application to individual patients. This series is targeted at physicians in practice or training.

《Best Practice and Research: Clinical Endocrinology and Metabolism》是一本专题系列出版物，旨在将最新的原创研究成果整合成实用的、基于证据的评论文章，解决诊断、治疗和患者管理等关键临床问题。每一期都围绕一个特定主题展开，重点关注需要解决的关键问题，明确已知信息，并突出未来研究的方向。管理策略以实际术语描述，以便能够应用于个体患者。该系列主要面向在临床实践或培训中的医生。

Best Practice and Research: Clinical Endocrinology and Metabolism

Animal models of endocrine disruption

Advances in genomics, neuroimaging and other tools are making a wider range of animal models more widely available to EDC researchers, and a greater diversity of species are used to effectively model more subtle but significant outcomes such as changes in pubertal timing, mammary gland development, and social behaviors.

Category	Quartile
医学	1
医学, 内分泌学与代谢	1

Animal models of endocrine disruption

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