Abstract The vessels of the central nervous system (CNS) have unique barrier properties. The endothelial cells (ECs) which comprise the CNS vessels contribute to the barrier via strong tight junctions, specific transporters, and limited endocytosis which combine to protect the brain from toxins and maintains brain homeostasis. Blood–brain barrier (BBB) leakage is a serious secondary injury in various CNS disorders like stroke, brain tumors, and neurodegenerative disorders. Currently, there are no drugs or therapeutics available to treat specifically BBB damage after a brain injury. Growing knowledge in the field of epigenetics can enhance the understanding of gene level of the BBB and has great potential for the development of novel therapeutic strategies or targets to repair a disrupted BBB. In this brief review, we summarize the epigenetic mechanisms or regulators that have a protective or disruptive role for components of BBB, along with the promising approaches to regain the integrity of BBB.

Stephanie A. Ihezie

Iny Elizebeth Mathew

Devin W. McBride

Ari Dienel

Spiros L. Blackburn

Peeyush Kumar Thankamani Pandit

Fluids and Barriers of the CNS

FLUIDS AND BARRIERS OF THE CNS 是一本开放获取、同行评审的期刊，考虑所有 CNS 液体和屏障系统在健康和疾病中的手稿。通过脑液和屏障的正常功能维持神经系统内部环境的稳态至关重要为了机体的健康。脑脊液 (CSF) 及其组成、循环和吸收在正常和异常的脑功能中具有多种作用，并且与脑实质间质液和血脑屏障处的神经血管单元密切相关。包括血脑脊液屏障、血脑屏障、血视网膜屏障和血神经屏障在内的中枢神经系统流体和屏障系统执行流体分泌、化学信号传导、物理和化学缓冲、专门的定向运输和促进免疫监视。

Fluids and Barriers of the CNS is an open-access, peer-reviewed journal that focuses on the study of central nervous system (CNS) fluids and barrier systems in health and disease. Cerebrospinal fluid (CSF) and its components, circulation, and absorption play critical roles in normal and abnormal brain function, closely interacting with the neurovascular unit at the brain parenchyma interstitial fluid and the blood-brain barrier. The fluid and barrier systems of the central nervous system, including the blood-cerebrospinal fluid barrier, blood-brain barrier, blood-retinal barrier, and blood-nerve barrier, are responsible for fluid secretion, chemical signaling, physical and chemical buffering, specialized directional transport, and facilitating immune surveillance, all of which are essential for maintaining the homeostasis of the internal environment of the nervous system.

《Fluids and Barriers of the CNS》是一本开放获取、同行评审的期刊，专注于中枢神经系统（CNS）液体和屏障系统在健康与疾病中的研究。脑脊液（CSF）及其成分、循环和吸收在正常和异常脑功能中发挥着重要作用，并与脑实质间质液和血脑屏障的神经血管单元密切相关。中枢神经系统的液体和屏障系统，包括血脑脊液屏障、血脑屏障、血视网膜屏障和血神经屏障，负责流体分泌、化学信号传导、物理和化学缓冲、特定的定向运输以及促进免疫监视，这些功能对于维持神经系统内部环境的稳态至关重要。

Epigenetics in blood–brain barrier disruption

The epigenetic mechanisms or regulators that have a protective or disruptive role for components of Blood–brain barrier, along with the promising approaches to regain the integrity of BBB are summarized.

Category	Quartile
医学	1
医学, 神经科学	2

Epigenetics in blood–brain barrier disruption

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