Biological applications of mass spectrometry have grown exponentially since the discovery of MALDI and electrospray ionization techniques. This growth has been further fueled by the massive volume of DNA sequence information that is now available. An ambitious goal of some of this research is to monitor the level and modification of all proteins and metabolites in a biological sample such as plasma. A major research effort in mass spectrometry and related disciplines has been expended over the past several years toward reaching this and other less ambitious goals, and considerable progress has been made; but the presently available tools are clearly not sufficient for these very difficult tasks. In this "critical insight" discussion we suggest that recent advances in time-of-flight (TOF) technology with MALDI ionization may provide some important new tools for achieving the goals of biological research.

Marvin L. Vestal

Journal of the American Society for Mass Spectrometry

《美国质谱学会杂志》发表的研究论文涵盖了质谱的各个方面，涵盖了质谱可以发挥作用的科学探究领域。该杂志发表的论文范围广泛，涉及质量的基础和应用光谱学。基础科目包括仪器原理、设计和演示、气相离子的结构和化学性质、热力学性质研究、离子光谱学、化学动力学、电离机制、离子碎裂理论、簇离子和势能表面。除了全文之外，该期刊还提供通讯、应用笔记、账户和观点

The Journal of the American Society for Mass Spectrometry publishes research papers covering all aspects of mass spectrometry, including its applications in various scientific inquiries. The journal features a wide range of papers that encompass both fundamental and applied spectroscopy. Fundamental topics include principles of instrumentation, design and demonstration, structure and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, ionization mechanisms, ion fragmentation theory, cluster ions, and potential energy surfaces. In addition to full articles, the journal also offers communications, application notes, accounts, and viewpoints.

《Journal of the American Society for Mass Spectrometry》发表的研究论文涵盖质谱的各个方面，涉及质谱在科学研究中的广泛应用。该杂志的论文范围广泛，涵盖基础和应用光谱学。基础主题包括仪器原理、设计与演示、气相离子的结构与化学性质、热力学性质研究、离子光谱学、化学动力学、电离机制、离子碎裂理论、簇离子和势能表面等。此外，期刊还提供通讯、应用笔记、账户和观点等内容。

The Future of Biological Mass Spectrometry

It is suggested that recent advances in time-of-flight (TOF) technology with MALDI ionization may provide some important new tools for achieving the goals of biological research.

Category	Quartile
化学	2
化学, 光谱学	2
化学, 生化研究方法	3
化学, 分析化学	3
化学, 物理化学	3

The Future of Biological Mass Spectrometry

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