Mitochondria are essential organelles in the human body, serving as the metabolic factory of the whole organism. When mitochondria are dysfunctional, it can affect all organs of the body. The kidney is rich in mitochondria, and its function is closely related to the development of kidney diseases. Studying the relationship between mitochondria and kidney disease progression is of great interest. In the past decade, scientists have made inspiring progress in investigating the role of mitochondria in the pathophysiology of renal diseases. This article discusses various mechanisms for maintaining mitochondrial quality, including mitochondrial energetics, mitochondrial biogenesis, mitochondrial dynamics, mitochondrial DNA repair, mitochondrial proteolysis and the unfolded protein response, mitochondrial autophagy, mitochondria-derived vesicles, and mitocytosis. The article also highlights the cross talk between mitochondria and other organelles, with a focus on kidney diseases. Finally, the article concludes with an overview of mitochondria-related clinical research.

Yuxian Guo

Ruochen Che

Peipei Wang

Aihua Zhang

AJP Renal Physiology

美国生理学杂志 - 肾脏生理学发表关于基础科学和临床研究的及时主题的原始手稿。已发表的文章涉及与肾脏和泌尿道相关的广泛主题，可能涉及人类或动物模型、单个细胞类型和分离的膜系统。还涵盖了肾脏疾病过程的病理生理学基础、体液调节以及提供机制见解的临床研究。可以使用广泛的方法进行肾功能研究，例如生物化学、免疫学、遗传学、数学建模、分子生物学以及生理学和临床方法。

The American Journal of Physiology - Renal Physiology publishes original manuscripts on timely topics in basic science and clinical research related to the kidneys and urinary tract. Published articles cover a wide range of subjects, potentially involving human or animal models, individual cell types, and isolated membrane systems. The journal also addresses the pathophysiological basis of kidney disease processes, fluid regulation, and clinical studies that provide mechanistic insights. Various methods can be employed for renal function research, including biochemistry, immunology, genetics, mathematical modeling, molecular biology, as well as physiological and clinical approaches.

《American Journal of Physiology - Renal Physiology》发表关于基础科学和临床研究的原创性文章，涵盖与肾脏及泌尿系统相关的广泛主题。这些研究可能涉及人类或动物模型、单个细胞类型以及分离的膜系统。期刊还探讨肾脏疾病的病理生理学基础、体液调节，以及提供机制见解的临床研究。肾功能研究的方法多种多样，包括生物化学、免疫学、遗传学、数学建模、分子生物学，以及生理学和临床方法。

American Journal of Physiology - Renal Physiology

Mitochondrial dysfunction in the pathophysiology of renal diseases

Various mechanisms for maintaining mitochondrial quality are discussed, including mitochondrial energetics, mitochondrial biogenesis, mitochondrial dynamics, mitochondrial DNA repair, mitochondrial proteolysis and UPR, mitochondrial autophagy, mitochondria-derived vesicles, and mitocytosis.

Category	Quartile
医学	2
医学, 生理学	2
医学, 泌尿学与肾脏学	2

Mitochondrial dysfunction in the pathophysiology of renal diseases

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Journal Info

Category	Quartile
UROLOGY & NEPHROLOGY	1