Introduction: We aimed to investigate electrophysiologically and histopathologically, the protective effects of intratympanic memantine, an N-methyl-D-aspartate receptor antagonist, on ototoxicity caused by cisplatin, an anti-neoplastic agent used in many types of cancer. Methods: Thirty-seven guinea pigs with a normal auditory function were randomly allocated to group 1 (Cisplatin; n=8), group 2 (Memantine; n=8), group 3 (Cisplatin+Memantine; n=8), group 4 (Cisplatin+Physiological Serum [PS]; n=8), and group 5 (Control; n=5). Auditory assessments were conducted using distortion product otoacoustic emissions (DPOAE) within a frequency range of 1-32 kHz, and auditory brainstem responses (ABR) within 8-32 kHz. A single dose of cisplatin (12 mg/kg) was administered intraperitoneally, followed by intratympanic administration of 0.2 mL of either memantine or PS to both ears at least half an hour before cisplatin administration. Subsequent auditory evaluations were conducted 72 h after cisplatin administration. Histopathological analyses were performed using light microscopy of the right ear and scanning electron microscopy (SEM) of the left ear. Results: Auditory evaluations conducted before and after treatment revealed significant findings. Specifically, within groups 3 and 4, ABR thresholds were elevated at all frequencies (p=0.00), whereas the DPOAE signal-to-noise ratios were reduced at frequencies of 8, 12, 16, and 24 kHz (p=0.001, p=0.01, p=0.01, and p=0.00, respectively). Histopathologically, both light microscopy and SEM revealed that the cisplatin+memantine group exhibited fewer hair cells and nuclear degeneration in the spiral ganglion than the cisplatin and cisplatin+PS groups. Additionally, the stria vascularis thickness was greater in the cisplatin+memantine group than in cisplatin and cisplatin+PS groups. Conclusion: Despite the negative electrophysiological findings, the histopathological outcomes suggest that intratympanic memantine may have a potential protective effect against cisplatin-induced ototoxicity. However, further investigations are warranted to corroborate these findings and elucidate the underlying mechanisms of action of memantine.

Selis Gülseven Güven

Hilal Erdoğan

Murat Arslan

Onur Ersoy

Erdoğan Bulut

Özlem Tuğçe Çilingir Kaya

Serap Sırvancı

Cem Uzun

Audiology and Neurotology

“听力学和神经病学”为发表与听觉和前庭系统以及耳部疾病的基础科学和临床方面相关的最先进和最严谨的科学研究提供了一个论坛。该杂志寻求提交前沿研究，开辟新的和创新的研究领域，这可能会提高我们对听觉和前庭系统疾病患者的理解和治疗，他们的中枢连接和他们在中枢神经系统中的感知。除了原创论文外，该杂志还提供由该领域领先专家撰写的关于当前主题的受邀评论文章。该杂志对所有对听力学、耳科和神经病学、听觉神经科学和相关学科感兴趣的科学家和从业者都至关重要。

"Audiology and Neurotology" provides a cutting-edge academic forum for fundamental and clinical research related to the auditory and vestibular systems, as well as ear diseases. The journal aims to publish innovative studies that explore new research areas, enhancing our understanding and treatment of patients with auditory and vestibular system disorders, particularly regarding their central connections and perceptions within the central nervous system. In addition to original research articles, the journal features invited review articles written by leading experts in the field, discussing current topics of interest. This journal is essential for all scientists and practitioners interested in audiology, otology, neurology, auditory neuroscience, and related disciplines.

《Audiology and Neurotology》为听觉和前庭系统以及耳部疾病的基础科学和临床研究提供了一个前沿的学术论坛。该杂志致力于发表创新性研究，探索新的研究领域，以增进我们对听觉和前庭系统疾病患者的理解和治疗，特别是他们的中枢连接及其在中枢神经系统中的感知。此外，杂志还刊登由该领域顶尖专家撰写的受邀评论文章，讨论当前的研究主题。对于所有关注听力学、耳科、神经病学、听觉神经科学及相关学科的科学家和从业者来说，该杂志具有重要的学术价值。

Category	Quartile
医学	4
医学, 听力学与言语病理学	4
医学, 神经科学	4
医学, 耳鼻喉科学	4

The Effects of Memantine on Cisplatin-induced Ototoxicity

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