Abstract Background and objectives Research suggests that diabetic peripheral neuropathy (DPN) is related to high serum uric acid (SUA) level, although its correlation with low SUA level has not been reported. Here, diabetic patients with hyperuricemia were excluded, and the correlation between low SUA level and DPN was explored. Subjects and methods This prospective observational clinical study enrolled 525 type 2 diabetes mellitus (T2DM) patients without hyperuricemia, who were divided into the diabetes with symptomatic neuropathy (150 cases), diabetes with asymptomatic neuropathy (125 cases) and diabetes with no neuropathy (250 cases) groups. Results The SUA slightly decreased in subjects with asymptomatic DPN compared with those with no neuropathy and greatly decreased in subjects with symptomatic DPN compared with those without ( P &lt; 0.001). The association of the SUA with diabetic neuropathy was independent of the hyperglycemic state and other potential confounders (odds ratio 0.985 [0.981–0.988], P &lt; 0.001). The SUA was closely correlated with the means of motor/sensory nerve amplitude and CV (all P &lt; 0.001). The optimal cut-off point for SUA to distinguish patients with diabetic neuropathy from those without was 324 umol/L, with a sensitivity of 76.0% and a specificity of 79.2% (AUC = 0.806). Conclusions The low SUA level is closely associated with DPN. Future studies are warranted to clarify the relationship.

Yong Zhuang

Huibin Huang

Xin Hu

Jinying Zhang

Qingyan Cai

Acta Neurologica Belgica

ACTA NEUROLOGICA BELGICA 经同行评审并每季度出版，发表临床和基础神经科学领域的原创文章，并报告不同合作伙伴协会科学会议的会议记录和摘要。内容包括评论、社论、评论文章、病例报告、感兴趣的神经图像、书评和致编辑的信。ACTA NEUROLOGICA BELGICA 是以下国家学会的官方期刊：BELGIAN NEUROLOGICAL SOCIETYBELGIAN SOCIETY FOR NEUROSCIENCEBELGIAN SOCIETY OF CLINICAL NEUROPHYSIOLOGYBELGIAN儿科神经病学学会比利时多发性硬化症研究组比利时中风委员会比利时头痛学会比利时神经病理学研究组

Acta Neurologica Belgica is a peer-reviewed journal published quarterly, focusing on original research articles in the fields of clinical and basic neuroscience. The journal also reports on scientific meeting records and abstracts from various partner associations. Content includes reviews, editorials, review articles, case reports, interesting neuroimaging studies, book reviews, and letters to the editor. Acta Neurologica Belgica is the official journal of the following national societies: Belgian Neurological Society, Belgian Society for Neuroscience, Belgian Society of Clinical Neurophysiology, Belgian Society of Pediatric Neurology, Belgian Multiple Sclerosis Research Group, Belgian Stroke Council, and Belgian Headache Society.

《Acta Neurologica Belgica》是一本经过同行评审的期刊，每季度出版一次，主要发表临床和基础神经科学领域的原创研究文章。此外，期刊还会报告不同合作伙伴协会的科学会议记录和摘要。内容涵盖评论、社论、综述文章、病例报告、神经影像学的相关研究、书评以及致编辑的信件。《Acta Neurologica Belgica》是以下国家学会的官方期刊：比利时神经病学学会、比利时神经科学学会、比利时临床神经生理学学会、比利时儿科神经病学学会、比利时多发性硬化症研究组、比利时中风委员会和比利时头痛学会。

Serum uric acid and diabetic peripheral neuropathy: a double-edged sword

The association of the SUA with diabetic neuropathy was independent of the hyperglycemic state and other potential confounders and closely correlated with the means of motor/sensory nerve amplitude and CV.

Category	Quartile
医学	4
医学, 临床神经病学	4
医学, 神经科学	4

Serum uric acid and diabetic peripheral neuropathy: a double-edged sword

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