In the clinical laboratory setting, interferences can be a significant source of laboratory errors with potential to cause serious harm for the patient. After hemolysis, lipemia is the most frequent endogenous interference that can influence results of various laboratory methods by several mechanisms. The most common preanalytical cause of lipemic samples is inadequate time of blood sampling after the meal or parenteral administration of synthetic lipid emulsions. Although the best way of detecting the degree of lipemia is measuring lipemic index on analytical platforms, laboratory experts should be aware of its problems, like false positive results and lack of standardization between manufacturers. Unlike for other interferences, lipemia can be removed and measurement can be done in a clear sample. However, a protocol for removing lipids from the sample has to be chosen carefully, since it is dependent on the analytes that have to be determined. Investigation of lipemia interference is an obligation of manufacturers of laboratory reagents; however, several literature findings report lack of verification of the declared data. Moreover, the acceptance criteria currently used by the most manufacturers are not based on biological variation and need to be revised. Written procedures for detection of lipemia, removing lipemia interference and reporting results from lipemic samples should be available to laboratory staff in order to standardize the procedure, reduce errors and increase patient safety.

Nora Nikolac

Biochemia Medica

BIOCHEMIA MEDICA 是克罗地亚医学生物化学和检验医学学会的官方同行评审期刊。该杂志广泛报道了临床化学和检验医学各个方面的研究。以下类别适合该杂志的范围：一般临床化学、血液学和止血、分子诊断和内分泌学。欢迎开发、验证和验证适用于临床化学和检验医学的分析技术和方法，以及涉及实验室组织、自动化和质量控制的研究。该杂志定期发表具有教育意义的分析前案例报告（分析前之谜）、有关应用生物统计学（生物统计学课程）和研究诚信（研究诚信角）的文章。

Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. The journal covers a wide range of research in clinical chemistry and laboratory medicine, including general clinical chemistry, hematology and hemostasis, molecular diagnostics, and endocrinology. We welcome studies on the development, validation, and application of analytical techniques and methods relevant to clinical chemistry and laboratory medicine, as well as research involving laboratory organization, automation, and quality control. Additionally, the journal regularly publishes educational pre-analytical case reports (pre-analytical mysteries), articles on applied biostatistics (biostatistics courses), and discussions on research integrity (research integrity corner).

《Biochemia Medica》是克罗地亚医学生物化学和检验医学学会的官方同行评审期刊。该期刊广泛报道临床化学和检验医学的各个方面，涵盖一般临床化学、血液学与止血、分子诊断和内分泌学等领域。我们欢迎关于适用于临床化学和检验医学的分析技术和方法的开发、验证和应用研究，以及涉及实验室组织、自动化和质量控制的相关研究。此外，该期刊定期发表具有教育意义的分析前案例报告（分析前之谜）、应用生物统计学的文章（生物统计学课程）以及关于研究诚信的讨论（研究诚信角）。

Lipemia: causes, interference mechanisms, detection and management

Written procedures for detection of lipemia, removing lipemia interference and reporting results from lipemic samples should be available to laboratory staff in order to standardize the procedure, reduce errors and increase patient safety.

Category	Quartile
医学	3
医学, 医学实验技术	3

Lipemia: causes, interference mechanisms, detection and management

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info

Category	Quartile
MEDICAL LABORATORY TECHNOLOGY	1