Benzocaine (ethyl p-aminobenzoate), ethyl ester of p-aminobenzoic acid, is an anesthetic acting as a blocker of the nerve impulses and reducing the permeability of neuronal membrane to sodium iodide, it has become widespread in the pharmaceutical industry having applications as an anesthetic prior to exams such as endoscopy or as a "retarding" agent when inserted in condom. Due to the wide insertion in the pharmaceutical market, the methodologies for obtaining this molecule have already been elucidated and published in the literature, however the application of traditional reactions in refined systems, such as continuous flow are a technological bottleneck that allow approaches aimed at the optimization of productivity. Thus, the present work aimed to apply the reduction and esterification of p-nitrobenzoic acid in one step continuous flow systems, optimizing the reaction time and sequences, in order to add relevance and technology to the process as a whole. The model applied in a continuous flow system generated extremely positive values compared to the present literature, which include results with high conversion (> 99%) and selectivity (> 99%), in residence times that reach up to a minimum of 12 s.

Alexandre de S. França

Raquel A. C. Leão

Rodrigo O. M. A. de Souza

Journal of Flow Chemistry

该杂志的主要关注点是学术研究中无机、有机、分析和过程化学中的流动化学以及制药、农用化学品、精细化工、石油化工、香料行业的应用研究和开发。

The Journal of Flow Chemistry primarily focuses on the application of flow chemistry in academic research, covering inorganic, organic, analytical, and process chemistry, as well as research and development in pharmaceuticals, agrochemicals, fine chemicals, petrochemicals, and the fragrance industry.

《Journal of Flow Chemistry》主要关注流动化学在学术研究中的应用，涵盖无机、有机、分析和过程化学领域，以及在制药、农用化学品、精细化工、石油化工和香料行业的研究与开发。

Two step continuous-flow synthesis of benzocaine

The present work aimed to apply the reduction and esterification of p -nitrobenzoic acid in one step continuous flow systems, optimizing the reaction time and sequences, in order to add relevance and technology to the process as a whole.

Category	Quartile
化学	4
化学, 化学综合	4

Two step continuous-flow synthesis of benzocaine

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	3