Purpose of review The chronic inflammatory bowel diseases (IBD), Crohn's disease, and ulcerative colitis, are associated with an increased risk of symptomatic Clostridium difficile infection (CDI). CDI may also masquerade as an IBD flare and complicate IBD management. This review provides a comprehensive overview of the epidemiology, diagnosis, and treatment of CDI in IBD patients. Recent findings CDI remains common in IBD with complications including flares in disease activity, recurrent CDI episodes, and prolonged hospital stays. Newer IBD therapeutics including vedolizumab, ustekinumab, and tofacitinib are less likely to cause severe CDI. A high index of suspicion, rapid testing via a two-step method, and prompt treatment with vancomycin or fidaxomicin are paramount to managing CDI in IBD patients. Strategies to prevent recurrent CDI (rCDI) include the monoclonal antibody bezlotoxumab as well as fecal microbiota transplantation (FMT). FMT has a robust profile of safety and effectiveness in preventing rCDI in adults and children. Summary Clinicians must remain vigilant in the prompt diagnosis and treatment of CDI in IBD patients. Corticosteroids, unnecessary antibiotics, and ongoing colonic inflammatory disease are modifiable risk factors. Improved infection control measures, newer IBD medications, and using effective CDI treatments will facilitate a reduced burden of severe CDI and complications for IBD patients.

Tamara Alhobayb

Matthew A. Ciorba

Current Opinion in Gastroenterology

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​每双月刊出版，并就该领域的关键发展提供独特而广泛的视角，每期《当前胃肠病学观点》都包含我们专家编辑团队精心挑选的评论文章。全年出版了十二个学科——包括胃肠道感染、营养和炎症性肠病——每期还包含注释参考文献，详细说明最重要论文的优点。

Current Opinion in Gastroenterology is a bimonthly journal that offers unique perspectives on key developments in the field. Each issue features carefully selected review articles by our expert editorial team, covering twelve disciplines including gastrointestinal infections, nutrition, and inflammatory bowel disease. Additionally, each issue includes annotated references that highlight the merits of the most significant papers.

《Current Opinion in Gastroenterology》是一本每两个月出版的期刊，提供该领域关键发展的独特视角。每期都包含由我们专家编辑团队精心挑选的评论文章，涵盖包括胃肠道感染、营养和炎症性肠病在内的十二个学科。此外，每期还附有注释参考文献，详细说明最重要论文的优点。

Clostridium difficile in inflammatory bowel disease

Clinicians must remain vigilant in the prompt diagnosis and treatment of CDI in IBD patients, and improve infection control measures, newer IBD medications, and using effective CDI treatments will facilitate a reduced burden of severe CDI and complications for IBD Patients.

Category	Quartile
医学	3
医学, 胃肠肝病学	4

Clostridium difficile in inflammatory bowel disease

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Journal Info

Category	Quartile
GASTROENTEROLOGY & HEPATOLOGY	2