Alkaloids are naturally occurring compounds with complex structures found in natural plants. To further improve the understanding of plant alkaloids, this review focuses on the classification, toxicity and mechanisms of action, providing insight into the occurrence of alkaloid-poisoning events and guiding the safe use of alkaloids in food, supplements and clinical applications. Based on their chemical structure, alkaloids can be divided into organic amines, diterpenoids, pyridines, isoquinolines, indoles, pyrrolidines, steroids, imidazoles and purines. The mechanisms of toxicity of alkaloids, including neurotoxicity, hepatoxicity, nephrotoxicity, cardiotoxicity and cytotoxicity, have also been reviewed. Some cases of alkaloid poisoning have been introduced when used as food or clinically, including accidental food poisoning, excessive consumption, and poisoning caused by the improper use of alkaloids in a clinical setting, and the importance of safety evaluation was illustrated. This review summarizes the toxicity and mechanism of action of alkaloids and provides evidence for the need for the safe use of alkaloids in food, supplements and clinical applications.

Nannan Yang

Jiafu Guo

Jian Zhang

Song Gao

Qiwen Xiang

Jiayu Wen

Yan Huang

Chaolong Rao

Yan Chen

Drug and Chemical Toxicology

DRUG AND CHEMICAL TOXICOLOGY 发表完整的研究论文、评论文章和简短的通讯，其中包含围绕风险评估和有害暴露的广泛毒理学数据。稿件根据其与期刊的相关性进行考虑。主题包括描述性和力学研究，说明接触有毒物质的风险评估影响。合适主题的示例包括毒理学研究，即对剂量、代谢和基于统计或基于机制的风险评估方法影响的结构检查。新的发现和方法以及安全性评估也是可以接受的。可以保留特刊以发表专题讨论会摘要、毒理学评论以及毒理学数据的实际解释和应用概述。

The journal "Drug and Chemical Toxicology" publishes complete research papers, review articles, and brief communications that encompass a wide range of toxicological data related to risk assessment and harmful exposures. Manuscripts are considered based on their relevance to the journal's themes. Suitable topics include descriptive and mechanistic studies that examine the impact of exposure to toxic substances on risk assessment. Examples of appropriate topics include toxicological research, particularly structural analyses of the effects of dose, metabolism, and statistical or mechanistic risk assessment methods. New findings, methodologies, and safety assessments are also accepted. Additionally, special issues may be reserved for publishing abstracts of symposium discussions, toxicological reviews, and practical interpretations and applications of toxicological data.

《Drug and Chemical Toxicology》期刊发表完整的研究论文、评论文章和简短的通讯，涵盖与风险评估和有害暴露相关的广泛毒理学数据。稿件将根据其与期刊主题的相关性进行考虑。适合的主题包括描述性和机制研究，探讨接触有毒物质的风险评估影响。合适的主题示例包括毒理学研究，特别是对剂量、代谢以及基于统计或机制的风险评估方法的影响进行结构性分析。新的发现、方法以及安全性评估也被接受。此外，期刊还会保留特刊，以发表专题讨论会摘要、毒理学评论以及毒理学数据的实际解释和应用概述。

A toxicological review of alkaloids

The toxicity and mechanism of action of alkaloids are summarized and evidence for the need for the safe use of alkaloids in food, supplements and clinical applications is provided.

Category	Quartile
医学	4
医学, 化学综合	3
医学, 药学	4
医学, 毒理学	4

A toxicological review of alkaloids

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