Four new bisindole alkaloids, cathagines A (1)-D (4) consisting of an aspidosperma and the fused tetracyclic 3-spirooxindole derived from an iboga type skeleton were isolated from the whole plant of Catharanthus roseus. The structures including absolute stereochemistry were elucidated on the basis of 2D NMR data and CD spectra. Cathagine B (2) showed moderate anti-malarial activity against Plasmodium falciparum 3D7.

Yusuke Hirasawa

Chiaki Kasagi

Erika Koyama

Hitomi Myojin

Takahiro Tougan

Toshihiro Horii

Nahoko Uchiyama

Toshio Kaneda

Hiroshi Morita

Journal of Natural Medicines

JOURNAL OF NATURAL MEDICINES 是一本国际期刊，发表有关天然药物及其相关食品和化妆品的原创研究。它涵盖：-天然产物化学-药用植物生物化学-天然产物和草药的药理学，包括汉方配方和传统草药-植物解剖学-药用植物的培养。该杂志接受原始论文、笔记、快速通讯和自然资源信件.通常会邀请评论和迷你评论。

The Journal of Natural Medicines is an international journal dedicated to publishing original research on natural medicines and their related foods and cosmetics. It covers the following areas: - Natural product chemistry - Biochemistry of medicinal plants - Pharmacology of natural products and herbs, including traditional Chinese formulations and herbal medicine - Plant anatomy - Cultivation of medicinal plants. The journal accepts original papers, notes, rapid communications, and letters on natural resources, and often invites reviews and mini-reviews.

《Journal of Natural Medicines》是一本国际期刊，专注于发表关于天然药物及其相关食品和化妆品的原创研究。期刊内容涵盖以下领域：- 天然产物化学 - 药用植物生物化学 - 天然产物和草药的药理学，包括汉方配方和传统草药 - 植物解剖学 - 药用植物的培养。该杂志接受原始论文、笔记、快速通讯和自然资源信件，通常也会邀请评论和迷你评论。

Category	Quartile
医学	4
医学, 药物化学	3
医学, 药学	3

Cathagines A–D, new bisindole alkaloids from Catharanthus roseus

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	3