Objective: The current study exemplifies the synthesis of silver nanoparticles using Muntingia calabura L. (Mc-AgNP’s) fruit extract utilizing a green approach and testing the efficacy of synthesized NP’s. Methods: The green synthesize approach was used to synthesis Mc-AgNP’s followed by characterization using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Energy Dispersive X-ray Spectroscopy (EDX), and Field Emission Scanning Electron Microscopy (FESEM). Radical scavenging activity was assessed using DPPH, FRAP, and H202, followed by antibacterial activity. Results: The characteristic features of synthesized Muntingia calabura silver nanoparticles (Mc-AgNP’s) were analyzed using FT-IR which particularizes different functional groups with a broadband at 3408 cm-1 representing hydroxyl (-OH) stretching a peak at 1593.27 cm-1 corresponds to C = O groups in amide whereas a dip at 1383 cm-1 represents C-N amine and C-O stretching of alcohol groups were found. The Crystallinity of synthesized Mc-AgNP’s exhibited face-centered cubic (fcc) crystalline structure and the bio-reduction of the silver ions in solution was monitored by Energy dispersive X-ray spectroscopy (EDX). The FESEM analysis indicates that Mc-AgNP’s were dispersed in the solution using micrographs and the size ranged from 10 to 60 nm. The synthesized Mc-AgNP’s efficiently scavenged free radicals in a dose-dependent manner with 69% for DPPH, 59.9% for FRAP, and 64% for H202 respectively. Further, the synthesized Mc-AgNP’s demonstrated a potent antimicrobial agent against tested bacterial and fungal strains with a maximum zone of inhibition observed in S. aureus, K. pneumonia, and P. vulgaris with 14.6, 13.8, and 12.4 mm. Similarly, antifungal activity with Trichoderma harzianum demonstrated the highest zone with 18 mm followed by Aspergillus oryzae with 7 mm. Conclusion: These results highlight the interesting potential of synthesized Mc-AgNP’s as an effective source of bioactive compounds with potent antioxidant and antibacterial activity.

SIDHRA SYED ZAMEER AHMED

SYED ZAMEER AHMED KHADER

ELAYABARATHI MURUGESAN VALLIAMMAL

SUNFIYA RAFEEK ALI

MOTHEES SENTHILKUMAR

MOHANAPRIYA VENKATACHALAM

NILAVENDAN SARAVANAN

DEEPTHY SENTHILKUMARAN

International Journal of Applied Pharmaceutics

International Journal of Applied Pharmaceutics (Int J App Pharm) is a peer-reviewed, bimonthly (onward March 2017) open access journal devoted to the excellence and research in the pure pharmaceutics. This Journal publishes original research work that contributes significantly to further the scientific knowledge in conventional dosage forms, formulation development and characterization, controlled and novel drug delivery, biopharmaceutics, pharmacokinetics, molecular drug design, polymer-based drug delivery, nanotechnology, nanocarrier based drug delivery, novel routes and modes of delivery; responsive delivery systems, prodrug design, development and characterization of the targeted drug delivery systems, ligand carrier interactions etc. However, the other areas which are related to the pharmaceutics are also entertained includes physical pharmacy and API (active pharmaceutical ingredients) analysis. The Journal publishes original research work either as a Original Article or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication in the Journal.

The International Journal of Applied Pharmaceutics (Int J App Pharm) is a peer-reviewed, bimonthly open access journal dedicated to excellence in research within the field of pure pharmaceutics. This journal publishes original research that significantly contributes to the advancement of scientific knowledge in conventional dosage forms, formulation development and characterization, controlled and novel drug delivery, biopharmaceutics, pharmacokinetics, molecular drug design, polymer-based drug delivery, nanotechnology, nanocarrier-based drug delivery, novel routes and modes of delivery, responsive delivery systems, prodrug design, development and characterization of targeted drug delivery systems, and ligand-carrier interactions. Additionally, other related areas within pharmaceutics, such as physical pharmacy and active pharmaceutical ingredient (API) analysis, are also welcomed. The journal publishes original research either as Original Articles or Short Communications, and Review Articles on current topics in these fields are also considered for publication.

《国际应用药剂学期刊》（International Journal of Applied Pharmaceutics）是一本经过同行评审的开放获取期刊，自2017年3月起每两个月出版一次，致力于纯药剂学领域的卓越研究。该期刊发表的原创研究工作显著推动了传统剂型、制剂开发与表征、控制释放与新型药物递送、生物药剂学、药物动力学、分子药物设计、基于聚合物的药物递送、纳米技术、基于纳米载体的药物递送、新的递送途径与方式、响应性递送系统、前药设计、靶向药物递送系统的开发与表征、配体载体相互作用等科学知识的进步。此外，期刊还接受与药剂学相关的其他领域的稿件，包括物理药剂学和活性药物成分（API）分析。期刊发表的原创研究工作可以是原创文章或简短通讯，针对上述领域的当前主题的综述文章也会被考虑发表。

MUNTINGIA CALABURA SILVER NANOPARTICLES DETERIORATE OXIDATIVE IMPAIRMENT WITH POTENT ANTIBACTERIAL ACTIVITY

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