SUMMARY Infections due to Acinetobacter spp. are among the most difficult to treat. Most are resistant to standard antibiotics, and there is difficulty in distinguishing colonizers from pathogens. This mini-review examines the available antibiotics that exhibit activity against these organisms and provides guidance as to which cultures are relevant and how to treat active infections. Antibiograms describing resistance mechanisms and the minimum inhibitory concentration (MIC) are essential to determine which agent or combination of agents should be used after confirmation of infection, utilizing clinical parameters and biomarkers such as procalcitonin. Directed therapy should be prompt as despite its reputation as a colonizer, the attributable mortality is high. However, although combination therapy is advised, no specific combination has definite evidence of superiority.

Guy A. Richards

Olga Perovic

Adrian J. Brink

Clinical Microbiology Reviews

临床微生物学评论 (CMR) 分析了临床微生物学和免疫学的最新发展，提供了该领域的当前知识状态，以及对有争议问题的平衡、发人深省的观点。

Clinical Microbiology Reviews analyzes the latest developments in clinical microbiology and immunology, providing the current state of knowledge in the field and offering balanced and thought-provoking perspectives on controversial issues.

《Clinical Microbiology Reviews》分析了临床微生物学和免疫学的最新发展，提供了该领域的当前知识状态，并对有争议的问题提出了平衡且发人深省的观点。

Category	Quartile
医学	1
医学, 微生物学	1

The challenges of difficult-to-treat Acinetobacter infections

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