Glucagon-like peptide 2 (GLP-2) is a member of family of peptides derived from the proglucagon gene expressed in the intestines, pancreas and brain. Tissue-specific posttranslational processing of proglucagon leads to GLP-2 and GLP-1 secretion from the intestine and glucagon secretion from the pancreas. GLP-2 and GLP-1 are co-secreted from the enteroendocrine L-cells located in distal intestine in response to enteral nutrient ingestion, especially carbohydrate and fat. GLP-2 secretion is mediated by direct nutrient stimulation of the L-cells and indirect action from enteroendocrine and neural inputs, including GIP, gastrin-releasing peptide (GRP) and the vagus nerve. GLP-2 is secreted as a 33-amino acid peptide and is rapidly cleaved by dipeptidylpeptidase IV (DPP-IV) to a truncated peptide which acts as a weak agonist with competitive antagonistic properties. GLP-2 acts to enhance nutrient absorption by inhibiting gastric motility and secretion and stimulating nutrient transport. GLP-2 also suppresses food intake when infused centrally. The trophic actions of GLP-2 are specific for the intestine and occur via stimulation of crypt cell proliferation and suppression of apoptosis in mucosal epithelial cells. GLP-2 reduces gut permeability, bacterial translocation and proinflammatory cytokine expression under conditions of intestinal inflammation and injury. The effects of GLP-2 are mediated by a G-protein-linked receptor that is localized to the intestinal mucosa and hypothalamus. The intestinal localization of the GLP-2R to neural and endocrine cells, but not enterocytes, suggests that its actions are mediated indirectly via a secondary signaling mechanism. The implications of GLP-2 in domestic animal production are largely unexplored. However, GLP-2 may have therapeutic application in treatment of gastrointestinal injury and diarrheal diseases that occur in developing neonatal and weanling animals.

D G Burrin

B Stoll

X Guan

Domestic animal endocrinology

家畜内分泌学发表关于家畜内分泌生理学研究的科学论文。也欢迎那些利用其他物种作为与家畜相关的临床或生产问题模型的手稿。涵盖的主题包括：经典和生殖内分泌学-临床和应用内分泌学-激素分泌的调节-激素作用-分子生物学-细胞因子-生长因子

The journal "Domestic Animal Endocrinology" focuses on research in the endocrinology of domestic animals. It welcomes manuscripts that utilize other species as models for clinical or production issues related to domestic animals. Topics covered include classical and reproductive endocrinology, clinical and applied endocrinology, regulation of hormone secretion, hormone action, molecular biology, cytokines, and growth factors.

《Domestic Animal Endocrinology》期刊专注于家畜内分泌生理学的研究，欢迎与家畜相关的临床或生产问题模型的手稿，尤其是那些利用其他物种的研究。期刊涵盖的主题包括经典和生殖内分泌学、临床和应用内分泌学、激素分泌的调节、激素作用、分子生物学、细胞因子和生长因子等。

Domestic Animal Endocrinology

Domest Anim Endocrinol

Glucagon-like peptide 2 function in domestic animals.

The trophic actions of GLP-2 are specific for the intestine and occur via stimulation of crypt cell proliferation and suppression of apoptosis in mucosal epithelial cells, which reduces gut permeability, bacterial translocation and proinflammatory cytokine expression under conditions of intestinal inflammation and injury.

Category	Quartile
农林科学	2
农林科学, 奶制品与动物科学	2
农林科学, 内分泌学与代谢	3

Glucagon-like peptide 2 function in domestic animals.

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Journal Info

Category	Quartile
ENDOCRINOLOGY & METABOLISM	3